DegronMD - Q8WU20(FRS2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P215Q	TCGA-09-2044	OV	TCGA	AESST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1111
p.P215Q	DO28923	OV	ICGC	AESST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1111
p.R466S	TCGA-43-8115	LUSC	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.6316
p.R466S	DO26440	LUSC	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.6316
p.L460R	TCGA-44-A47B	LUAD	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1667
p.L460R	DO45353	LUAD	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1667
p.S221C	TCGA-A2-A0EQ	BRCA	TCGA	AESST	DEG_SPOP_SBC_1	223:227	Mutation blocking phosphorylation signal	0.7222
p.S221C	DO4773	BRCA	ICGC	AESST	DEG_SPOP_SBC_1	223:227	Mutation blocking phosphorylation signal	0.7222
p.A223T	TCGA-AP-A0LM	UCEC	TCGA	AESST	DEG_SPOP_SBC_1	223:227	Mutation altering degron motif	0.7139
p.A223T	TCGA-AP-A1DK	UCEC	TCGA	AESST	DEG_SPOP_SBC_1	223:227	Mutation altering degron motif	0.7139
p.A223T	DO43306	UCEC	ICGC	AESST	DEG_SPOP_SBC_1	223:227	Mutation altering degron motif	0.7139
p.A223T	DO42033	UCEC	ICGC	AESST	DEG_SPOP_SBC_1	223:227	Mutation altering degron motif	0.7139
p.S483P	TCGA-AP-A0LM	UCEC	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.0833
p.S483P	DO43306	UCEC	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.0833
p.S221F	TCGA-AR-A2LE	BRCA	TCGA	AESST	DEG_SPOP_SBC_1	223:227	Mutation blocking phosphorylation signal	0.7222
p.S221F	DO1932	BRCA	ICGC	AESST	DEG_SPOP_SBC_1	223:227	Mutation blocking phosphorylation signal	0.7222
p.E231Q	TCGA-B5-A0JX	UCEC	TCGA	AESST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.2222
p.E231Q	DO43322	UCEC	ICGC	AESST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.2222
p.E231A	TCGA-B5-A0JX	UCEC	TCGA	AESST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.2222
p.E231A	DO43322	UCEC	ICGC	AESST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.2222
p.R219M	TCGA-D3-A2JC	SKCM	TCGA	AESST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.2222
p.R219M	DO46777	PAEN	ICGC	AESST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.2222
p.R219M	DO47578	SKCM	ICGC	AESST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.2222
p.A472V	TCGA-D9-A4Z3	SKCM	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.5825
p.A472V	TCGA-D9-A6EC	SKCM	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.5825
p.A472V	DO50291	SKCM	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.5825
p.A472V	DO47555	SKCM	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.5825
p.L460I	TCGA-DA-A1IB	SKCM	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1667
p.L460I	DO38033	SKCM	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.1667
p.S233I	TCGA-DF-A2KN	UCEC	TCGA	AESST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1667
p.S233I	DO223282	UCEC	ICGC	AESST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1667
p.R467C	TCGA-HU-A4G8	STAD	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.8301
p.R467C	DO47819	STAD	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation altering degron motif	0.8301
p.E477D	TCGA-LT-A5Z6	BLCA	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.25
p.E477D	DO44029	BLCA	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation rewiring degron network	0.25
p.T463I	DO18392	KIRC	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	466:474	Mutation blocking phosphorylation signal	0.6944
p.E217K	SIDM01588	Endometrial Carcinoma	GDSC	AESST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1667
p.E217K	ACH-000993	Endometrial/Uterine Cancer	CCLE	AESST	DEG_SPOP_SBC_1	223:227	Mutation rewiring degron network	0.1667

Kaplan plot for FRS2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FRS2

UniProt ID: Q8WU20

Entrez ID: 10818

Protein name: Fibroblast growth factor receptor substrate 2 (FGFR substrate 2) (FGFR-signaling adaptor SNT) (Suc1-associated neurotrophic factor target 1) (SNT-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FRS2 in