DegronMD

Uniprot ID: Q8WU20

Source protein: Fibroblast growth factor receptor substrate 2

Source gene: FRS2

Class: DEG_APCC_DBOX_1

Location: 466:474

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6427

ASA_SCORE: 71.7667

COIL: 0.4911

CONS_SCORE: 0.6076

DSS_SCORE: 0.5708

HELIX: 0.2309

FCONS_SCORE: 1.0262

RIG_SCORE: 0.8314

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R466S	TCGA-43-8115	LUSC	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	0.6316
p.R466S	DO26440	LUSC	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	0.6316
p.L460R	TCGA-44-A47B	LUAD	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	0.1667
p.L460R	DO45353	LUAD	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	0.1667
p.S483P	TCGA-AP-A0LM	UCEC	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	0.0833
p.S483P	DO43306	UCEC	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	0.0833
p.A472V	TCGA-D9-A4Z3	SKCM	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	0.5825
p.A472V	TCGA-D9-A6EC	SKCM	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	0.5825
p.A472V	DO50291	SKCM	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	0.5825
p.A472V	DO47555	SKCM	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	0.5825
p.L460I	TCGA-DA-A1IB	SKCM	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	0.1667
p.L460I	DO38033	SKCM	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	0.1667
p.R467C	TCGA-HU-A4G8	STAD	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	0.8301
p.R467C	DO47819	STAD	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	0.8301
p.E477D	TCGA-LT-A5Z6	BLCA	TCGA	RRTELYAVI	DEG_APCC_DBOX_1	0.25
p.E477D	DO44029	BLCA	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	0.25
p.T463I	DO18392	KIRC	ICGC	RRTELYAVI	DEG_APCC_DBOX_1	0.6944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WU20	Fibroblast growth factor receptor substrate 2	DEG_APCC_DBOX_1	466:474	RRTELYAVI	APC,CDC20,FZR1	0.6427	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons