DegronMD

Uniprot ID: Q8WXI7

Source protein: Mucin-16

Source gene: MUC16

Class: DEG_SPOP_SBC_1

Location: 12359:12363

E3 ligase: SPOP

DEGRON score: 0.8271

ASA_SCORE: 71.66

COIL: 0.8746

CONS_SCORE: 0

DSS_SCORE: 0.5771

HELIX: 0.029

FCONS_SCORE: 0

RIG_SCORE: 0.6615

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G12360W	TCGA-50-7109	LUAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.6714
p.G12360W	DO24487	LUAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.6714
p.G12370A	TCGA-62-A46O	LUAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.1389
p.G12370A	DO26240	LUAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.1389
p.P12372Q	TCGA-66-2783	LUSC	TCGA	PGTST	DEG_SPOP_SBC_1	0.0833
p.P12372Q	DO26452	LUSC	ICGC	PGTST	DEG_SPOP_SBC_1	0.0833
p.H12349N	TCGA-75-6211	LUAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.0556
p.H12349N	DO25173	LUAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.0556
p.T12371S	TCGA-CC-A1HT	LIHC	TCGA	PGTST	DEG_SPOP_SBC_1	0.1111
p.T12371S	DO23028	LIHC	ICGC	PGTST	DEG_SPOP_SBC_1	0.1111
p.S12369L	TCGA-CV-7406	HNSC	TCGA	PGTST	DEG_SPOP_SBC_1	0.6111
p.S12369L	DO15422	HNSC	ICGC	PGTST	DEG_SPOP_SBC_1	0.6111
p.R12367K	TCGA-EB-A3Y7	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.2222
p.R12367K	DO37499	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.2222
p.P12359S	TCGA-EB-A5UM	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.6752
p.P12359S	TCGA-EE-A3JA	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.6752
p.P12359S	DO47282	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.6752
p.P12359S	DO47625	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.6752
p.G12360E	TCGA-EE-A2GC	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.6087
p.G12360E	DO37839	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.6087
p.L12366I	TCGA-EY-A1GI	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	0.25
p.L12366I	DO41211	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.S12352F	TCGA-F5-6814	READ	TCGA	PGTST	DEG_SPOP_SBC_1	0.1389
p.S12352F	DO36556	READ	ICGC	PGTST	DEG_SPOP_SBC_1	0.1389
p.L12366R	DO50411	ESAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.T12368P	DO233688	GACA	ICGC	PGTST	DEG_SPOP_SBC_1	0.6389
p.L12366P	DO233749	GACA	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.L12366F	DO233749	GACA	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.S12373F	DO229177	LMS	ICGC	PGTST	DEG_SPOP_SBC_1	0.0556
p.Q12350K	DO229216	THCA	ICGC	PGTST	DEG_SPOP_SBC_1	0.0833
p.R12367G	SIDM00781	Colorectal Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.2222
p.R12367G	SIDM00780	Colorectal Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.2222
p.R12367G	ACH-000967	Colon/Colorectal Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.2222
p.R12367G	ACH-001199	Colon/Colorectal Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.2222
p.R12367G	SNU-C2B	large_intestine	COSMIC	PGTST	DEG_SPOP_SBC_1	0.2222
p.D12365H	SIDM00365	Small Cell Lung Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.2778
p.D12365H	ACH-002196	Lung Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.2778
p.D12365H	SBC-1	lung	COSMIC	PGTST	DEG_SPOP_SBC_1	0.2778

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	249:253	PGTST	SPOP	0.9835	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1981:1985	PGTST	SPOP	0.9944	More...
O95255	ATP-binding cassette sub-family C member 6	DEG_SPOP_SBC_1	867:871	PGTST	SPOP	0.7523	More...
P02751	Fibronectin	DEG_SPOP_SBC_1	2242:2246	PGTST	SPOP	0.9855	More...
P24592	Insulin-like growth factor-binding protein 6	DEG_SPOP_SBC_1	141:145	PGTST	SPOP	0.9935	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	329:333	PGTST	SPOP	0.9981	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	1253:1257	PGTST	SPOP	0.5326	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	514:518	PGTST	SPOP	0.9981	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	212:216	PGTST	SPOP	0.5286	More...
Q8NAP3	Zinc finger and BTB domain-containing protein 38	DEG_SPOP_SBC_1	825:829	PGTST	SPOP	0.7458	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	1293:1297	PGTST	SPOP	0.8833	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12203:12207	PGTST	SPOP	0.9874	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12359:12363	PGTST	SPOP	0.8271	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12517:12521	PGTST	SPOP	0.5411	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12828:12832	PGTST	SPOP	0.9788	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12984:12988	PGTST	SPOP	0.9729	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	81:85	PGTST	SPOP	0.9892	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	553:557	PGTST	SPOP	0.979	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	868:872	PGTST	SPOP	0.9813	More...
Q9H4F8	SPARC-related modular calcium-binding protein 1	DEG_SPOP_SBC_1	281:285	PGTST	SPOP	0.8861	More...
Q496Y0	LON peptidase N-terminal domain and RING finger protein 3	DEG_SPOP_SBC_1	60:64	PGTST	SPOP	0.9986	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	286:290	PGTST	SPOP	0.9983	More...
Q96G46	tRNA-dihydrouridine	DEG_SPOP_SBC_1	269:273	PGTST	SPOP	0.9172	More...
Q9BZA0	Putative transcript Y 10 protein	DEG_SPOP_SBC_1	39:43	PGTST	SPOP	0.938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTST

Degron related mutations and impact score

Drug responses associated with MUC16 mutations

All proteins holding degron of PGTST