DegronMD - Q96G46(DUS3L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A267V	TCGA-86-A4JF	LUAD	TCGA	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.2778
p.A267V	DO45317	LUAD	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.2778
p.A267V	DO48177	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.2778
p.A267S	TCGA-86-A4JF	LUAD	TCGA	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.2778
p.A267S	DO45317	LUAD	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.2778
p.P278R	TCGA-BS-A0UV	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.P278R	DO42793	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1944
p.G268W	TCGA-GN-A4U5	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.3056
p.G268W	DO51257	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.3056
p.M268L	DO44400	CESC	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.3056
p.R266C	DO234362	ESAD	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.25
p.A281V	DO233652	GACA	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation blocking phosphorylation signal	0.5556
p.R279S	DO14278	HNSC	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1667
p.R279S	DO37515	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1667
p.R279S	DO38328	STAD	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1667
p.R279C	DO219125	LUSC	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1667
p.G280D	DO46657	PAAD	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1389
p.R266S	DO37515	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.25
p.G274W	DO37794	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.3056
p.R279L	DO37971	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1667
p.Q269H	DO229234	THCA	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation altering degron motif	0.7582
p.T273A	DO42023	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation altering degron motif	0.825
p.T273I	SIDM01293	Colorectal Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation altering degron motif	0.8189
p.V279M	SIDM00656	Burkitt's Lymphoma	GDSC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1667
p.V279M	SIDM00954	Breast Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1667
p.V279M	SIDM00641	Burkitt's Lymphoma	GDSC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1667
p.A262S	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1389
p.A262S	ACH-000929	Lung Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1389
p.A262S	NCI-H2110	lung	COSMIC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1389
p.C260Y	ACH-001289	Rhabdoid	CCLE	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.0833
p.R280Q	ACH-001863	Bile Duct Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	269:273	Mutation rewiring degron network	0.1389
p.M276V	SW48	large intestine	COSMIC	PGTST	DEG_SPOP_SBC_1	269:273	Mutation blocking phosphorylation signal	0.6944

Kaplan plot for DUS3L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DUS3L

UniProt ID: Q96G46

Entrez ID: 56931

Protein name: tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like (EC 1.3.1.89) (mRNA-dihydrouridine synthase DUS3L) (EC 1.3.1.-) (tRNA-dihydrouridine synthase 3-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DUS3L in