DegronMD - Q9H4F8(SMOC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R278H	TCGA-63-A5MM	LUSC	TCGA	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.R278H	TCGA-G4-6309	COAD	TCGA	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.R278H	DO7810	COAD	ICGC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.R278H	DO219153	LUSC	ICGC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.R278H	SIDM01772	Mesothelioma	GDSC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.R278H	ACH-000531	Non-Cancerous	CCLE	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.R278C	TCGA-99-8025	LUAD	TCGA	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.R278C	TCGA-LN-A8I1	ESCA	TCGA	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.R278C	DO24255	LUAD	ICGC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.V288M	TCGA-D5-6530	COAD	TCGA	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.V288M	DO8312	COAD	ICGC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.V288M	DO51959	PRAD	ICGC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.25
p.R286H	TCGA-EE-A3JA	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.3056
p.R286H	DO47625	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.3056
p.R286H	SIDM00377	Other Sarcomas	GDSC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.3056
p.R286H	SKN	soft tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.3056
p.S294N	DO224977	BRCA	ICGC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.0833
p.P279A	SIDM00120	Prostate Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2778
p.P279A	ACH-000979	Prostate Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2778
p.P279A	DU-145	prostate	COSMIC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2778
p.M289I	SIDM00537	Colorectal Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2222
p.M289I	ACH-000982	Colon/Colorectal Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2222
p.M289I	ACH-001345	Colon/Colorectal Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2222
p.M289I	GP5d	large intestine	COSMIC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.2222
p.C292S	SIDM01617	Endometrial Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1389
p.C292S	ACH-000994	Endometrial/Uterine Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	281:285	Mutation rewiring degron network	0.1389

Kaplan plot for SMOC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SMOC1

UniProt ID: Q9H4F8

Entrez ID: 64093

Protein name: SPARC-related modular calcium-binding protein 1 (Secreted modular calcium-binding protein 1) (SMOC-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SMOC1 in