DegronMD

Uniprot ID: Q9H4F8

Source protein: SPARC-related modular calcium-binding protein 1

Source gene: SMOC1

Class: DEG_SPOP_SBC_1

Location: 281:285

E3 ligase: SPOP

DEGRON score: 0.8861

ASA_SCORE: 58.18

COIL: 0.7284

CONS_SCORE: 0.6758

DSS_SCORE: 0.3511

HELIX: 0.0706

FCONS_SCORE: 1.1053

RIG_SCORE: 0.7155

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R278H	TCGA-63-A5MM	LUSC	TCGA	PGTST	DEG_SPOP_SBC_1	0.25
p.R278H	TCGA-G4-6309	COAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.25
p.R278H	DO7810	COAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.R278H	DO219153	LUSC	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.R278H	SIDM01772	Mesothelioma	GDSC	PGTST	DEG_SPOP_SBC_1	0.25
p.R278H	ACH-000531	Non-Cancerous	CCLE	PGTST	DEG_SPOP_SBC_1	0.25
p.R278C	TCGA-99-8025	LUAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.25
p.R278C	TCGA-LN-A8I1	ESCA	TCGA	PGTST	DEG_SPOP_SBC_1	0.25
p.R278C	DO24255	LUAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.V288M	TCGA-D5-6530	COAD	TCGA	PGTST	DEG_SPOP_SBC_1	0.25
p.V288M	DO8312	COAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.V288M	DO51959	PRAD	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.R286H	TCGA-EE-A3JA	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.3056
p.R286H	DO47625	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.3056
p.R286H	SIDM00377	Other Sarcomas	GDSC	PGTST	DEG_SPOP_SBC_1	0.3056
p.R286H	SKN	soft_tissue	COSMIC	PGTST	DEG_SPOP_SBC_1	0.3056
p.S294N	DO224977	BRCA	ICGC	PGTST	DEG_SPOP_SBC_1	0.0833
p.P279A	SIDM00120	Prostate Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.2778
p.P279A	ACH-000979	Prostate Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.2778
p.P279A	DU-145	prostate	COSMIC	PGTST	DEG_SPOP_SBC_1	0.2778
p.M289I	SIDM00537	Colorectal Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.2222
p.M289I	ACH-000982	Colon/Colorectal Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.2222
p.M289I	ACH-001345	Colon/Colorectal Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.2222
p.M289I	GP5d	large_intestine	COSMIC	PGTST	DEG_SPOP_SBC_1	0.2222
p.C292S	SIDM01617	Endometrial Carcinoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.1389
p.C292S	ACH-000994	Endometrial/Uterine Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	249:253	PGTST	SPOP	0.9835	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1981:1985	PGTST	SPOP	0.9944	More...
O95255	ATP-binding cassette sub-family C member 6	DEG_SPOP_SBC_1	867:871	PGTST	SPOP	0.7523	More...
P02751	Fibronectin	DEG_SPOP_SBC_1	2242:2246	PGTST	SPOP	0.9855	More...
P24592	Insulin-like growth factor-binding protein 6	DEG_SPOP_SBC_1	141:145	PGTST	SPOP	0.9935	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	329:333	PGTST	SPOP	0.9981	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	1253:1257	PGTST	SPOP	0.5326	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	514:518	PGTST	SPOP	0.9981	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	212:216	PGTST	SPOP	0.5286	More...
Q8NAP3	Zinc finger and BTB domain-containing protein 38	DEG_SPOP_SBC_1	825:829	PGTST	SPOP	0.7458	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	1293:1297	PGTST	SPOP	0.8833	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12203:12207	PGTST	SPOP	0.9874	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12359:12363	PGTST	SPOP	0.8271	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12517:12521	PGTST	SPOP	0.5411	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12828:12832	PGTST	SPOP	0.9788	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12984:12988	PGTST	SPOP	0.9729	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	81:85	PGTST	SPOP	0.9892	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	553:557	PGTST	SPOP	0.979	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	868:872	PGTST	SPOP	0.9813	More...
Q9H4F8	SPARC-related modular calcium-binding protein 1	DEG_SPOP_SBC_1	281:285	PGTST	SPOP	0.8861	More...
Q496Y0	LON peptidase N-terminal domain and RING finger protein 3	DEG_SPOP_SBC_1	60:64	PGTST	SPOP	0.9986	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	286:290	PGTST	SPOP	0.9983	More...
Q96G46	tRNA-dihydrouridine	DEG_SPOP_SBC_1	269:273	PGTST	SPOP	0.9172	More...
Q9BZA0	Putative transcript Y 10 protein	DEG_SPOP_SBC_1	39:43	PGTST	SPOP	0.938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTST

Degron related mutations and impact score

Drug responses associated with SMOC1 mutations

All proteins holding degron of PGTST