DegronMD

Uniprot ID: O95255

Source protein: ATP-binding cassette sub-family C member 6

Source gene: ABCC6

Class: DEG_SPOP_SBC_1

Location: 867:871

E3 ligase: SPOP

DEGRON score: 0.7523

ASA_SCORE: 74.28

COIL: 0.9102

CONS_SCORE: 0.2548

DSS_SCORE: 0.8573

HELIX: 0.0504

FCONS_SCORE: 1.0413

RIG_SCORE: 0.5551

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G868W	TCGA-18-3410	LUSC	TCGA	PGTST	DEG_SPOP_SBC_1	0.6714
p.G868W	DO26456	LUSC	ICGC	PGTST	DEG_SPOP_SBC_1	0.6714
p.S878F	TCGA-A5-A2K5	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	0.1389
p.S878F	DO41379	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	0.1389
p.G876C	TCGA-B5-A1MX	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	0.1944
p.G876C	DO41999	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	0.1944
p.E864K	TCGA-B5-A3FC	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	0.25
p.E864K	DO41871	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	0.25
p.G863R	TCGA-D3-A1Q6	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.2222
p.G863R	DO37450	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.2222
p.G863E	TCGA-D3-A2JO	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.2222
p.G863E	DO47619	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.2222
p.G861E	TCGA-D3-A8GO	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	0.1667
p.G861E	DO51242	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	0.1667
p.G861E	ACH-002672	Pancreatic Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.1667
p.G880C	DO222454	BTCA	ICGC	PGTST	DEG_SPOP_SBC_1	0.0833
p.R875K	SIDM00545	Melanoma	GDSC	PGTST	DEG_SPOP_SBC_1	0.2222
p.R875K	ACH-000987	Skin Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	0.2222
p.R875K	Mewo	skin	COSMIC	PGTST	DEG_SPOP_SBC_1	0.2222
p.E863A	HCC1500	breast	COSMIC	PGTST	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O15178	T-box transcription factor T	DEG_SPOP_SBC_1	249:253	PGTST	SPOP	0.9835	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	1981:1985	PGTST	SPOP	0.9944	More...
O95255	ATP-binding cassette sub-family C member 6	DEG_SPOP_SBC_1	867:871	PGTST	SPOP	0.7523	More...
P02751	Fibronectin	DEG_SPOP_SBC_1	2242:2246	PGTST	SPOP	0.9855	More...
P24592	Insulin-like growth factor-binding protein 6	DEG_SPOP_SBC_1	141:145	PGTST	SPOP	0.9935	More...
Q04726	Transducin-like enhancer protein 3	DEG_SPOP_SBC_1	329:333	PGTST	SPOP	0.9981	More...
Q12816	Trophinin	DEG_SPOP_SBC_1	1253:1257	PGTST	SPOP	0.5326	More...
Q2KHR2	DNA-binding protein RFX7	DEG_SPOP_SBC_1	514:518	PGTST	SPOP	0.9981	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	212:216	PGTST	SPOP	0.5286	More...
Q8NAP3	Zinc finger and BTB domain-containing protein 38	DEG_SPOP_SBC_1	825:829	PGTST	SPOP	0.7458	More...
Q8WWQ0	PH-interacting protein	DEG_SPOP_SBC_1	1293:1297	PGTST	SPOP	0.8833	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12203:12207	PGTST	SPOP	0.9874	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12359:12363	PGTST	SPOP	0.8271	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12517:12521	PGTST	SPOP	0.5411	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12828:12832	PGTST	SPOP	0.9788	More...
Q8WXI7	Mucin-16	DEG_SPOP_SBC_1	12984:12988	PGTST	SPOP	0.9729	More...
Q96PU4	E3 ubiquitin-protein ligase UHRF2	DEG_SPOP_SBC_1	81:85	PGTST	SPOP	0.9892	More...
Q96QS3	Homeobox protein ARX	DEG_SPOP_SBC_1	553:557	PGTST	SPOP	0.979	More...
Q96RK0	Protein capicua homolog	DEG_SPOP_SBC_1	868:872	PGTST	SPOP	0.9813	More...
Q9H4F8	SPARC-related modular calcium-binding protein 1	DEG_SPOP_SBC_1	281:285	PGTST	SPOP	0.8861	More...
Q496Y0	LON peptidase N-terminal domain and RING finger protein 3	DEG_SPOP_SBC_1	60:64	PGTST	SPOP	0.9986	More...
Q86X27	Ras-specific guanine nucleotide-releasing factor RalGPS2	DEG_SPOP_SBC_1	286:290	PGTST	SPOP	0.9983	More...
Q96G46	tRNA-dihydrouridine	DEG_SPOP_SBC_1	269:273	PGTST	SPOP	0.9172	More...
Q9BZA0	Putative transcript Y 10 protein	DEG_SPOP_SBC_1	39:43	PGTST	SPOP	0.938	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PGTST

Degron related mutations and impact score

Drug responses associated with ABCC6 mutations

All proteins holding degron of PGTST