DegronMD - O95255(ABCC6)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G868W	TCGA-18-3410	LUSC	TCGA	PGTST	DEG_SPOP_SBC_1	867:871	Mutation altering degron motif	0.6714
p.G868W	DO26456	LUSC	ICGC	PGTST	DEG_SPOP_SBC_1	867:871	Mutation altering degron motif	0.6714
p.S878F	TCGA-A5-A2K5	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1389
p.S878F	DO41379	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1389
p.G876C	TCGA-B5-A1MX	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1944
p.G876C	DO41999	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1944
p.E864K	TCGA-B5-A3FC	UCEC	TCGA	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.25
p.E864K	DO41871	UCEC	ICGC	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.25
p.G863R	TCGA-D3-A1Q6	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2222
p.G863R	DO37450	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2222
p.G863E	TCGA-D3-A2JO	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2222
p.G863E	DO47619	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2222
p.G861E	TCGA-D3-A8GO	SKCM	TCGA	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1667
p.G861E	DO51242	SKCM	ICGC	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1667
p.G861E	ACH-002672	Pancreatic Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.1667
p.G880C	DO222454	BTCA	ICGC	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.0833
p.R875K	SIDM00545	Melanoma	GDSC	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2222
p.R875K	ACH-000987	Skin Cancer	CCLE	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2222
p.R875K	Mewo	skin	COSMIC	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2222
p.E863A	HCC1500	breast	COSMIC	PGTST	DEG_SPOP_SBC_1	867:871	Mutation rewiring degron network	0.2222

Kaplan plot for ABCC6 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ABCC6

UniProt ID: O95255

Entrez ID: 368

Protein name: ATP-binding cassette sub-family C member 6 (EC 7.6.2.-) (EC 7.6.2.3) (Anthracycline resistance-associated protein) (Multi-specific organic anion transporter E) (MOAT-E) (Multidrug resistance-associated protein 6)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for ABCC6 in