DegronMD

Uniprot ID: Q5T8A7

Source protein: Protein phosphatase 1 regulatory subunit 26

Source gene: PPP1R26

Class: DEG_SCF_TRCP1_1

Location: 1200:1205

E3 ligase: BTRC

DEGRON score: 0.8355

ASA_SCORE: 66.8333

COIL: 0.8305

CONS_SCORE: 0.3808

DSS_SCORE: 0.7154

HELIX: 0.087

FCONS_SCORE: 0.8574

RIG_SCORE: 0.5811

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1206A	TCGA-DI-A1BU	UCEC	TCGA	DSGGSS	DEG_SCF_TRCP1_1	0.3056
p.V1206A	DO42023	UCEC	ICGC	DSGGSS	DEG_SCF_TRCP1_1	0.3056
p.D1192G	DO222856	COCA	ICGC	DSGGSS	DEG_SCF_TRCP1_1	0.1111
p.E1199D	DO229006	LICA	ICGC	DSGGSS	DEG_SCF_TRCP1_1	0.3056
p.T1198M	DO29308	OV	ICGC	DSGGSS	DEG_SCF_TRCP1_1	0.2778
p.V1206L	ACH-000634	Brain Cancer	CCLE	DSGGSS	DEG_SCF_TRCP1_1	0.3056
p.G1202V	ACH-000851	Lung Cancer	CCLE	DSGGSS	DEG_SCF_TRCP1_1	0.7532

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5T8A7	Protein phosphatase 1 regulatory subunit 26	DEG_SCF_TRCP1_1	1200:1205	DSGGSS	BTRC	0.8355	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons