DegronMD

Uniprot ID: Q5JV73

Source protein: FERM and PDZ domain-containing protein 3

Source gene: FRMPD3

Class: DEG_SCF_FBW7_1

Location: 1142:1149

E3 ligase: FBXW7

DEGRON score: 0.97

ASA_SCORE: 108.325

COIL: 0.8485

CONS_SCORE: 0.3215

DSS_SCORE: 0.6561

HELIX: 0.1301

FCONS_SCORE: 1.1469

RIG_SCORE: 0.6681

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1154N	TCGA-17-Z060	LUAD	TCGA	LESTPKRS	DEG_SCF_FBW7_1	0.1944
p.E1143D	TCGA-55-A48Y	LUAD	TCGA	LESTPKRS	DEG_SCF_FBW7_1	0.5647
p.E1143D	DO26160	LUAD	ICGC	LESTPKRS	DEG_SCF_FBW7_1	0.5647
p.E1152K	TCGA-AJ-A3EK	UCEC	TCGA	LESTPKRS	DEG_SCF_FBW7_1	0.25
p.E1152K	DO41584	UCEC	ICGC	LESTPKRS	DEG_SCF_FBW7_1	0.25
p.K1139N	TCGA-D1-A17Q	UCEC	TCGA	LESTPKRS	DEG_SCF_FBW7_1	0.3611
p.K1139N	DO41903	UCEC	ICGC	LESTPKRS	DEG_SCF_FBW7_1	0.3611
p.A1140V	TCGA-IQ-A61K	HNSC	TCGA	LESTPKRS	DEG_SCF_FBW7_1	0.2778
p.A1140V	DO228542	GACA	ICGC	LESTPKRS	DEG_SCF_FBW7_1	0.2778
p.A1140V	DO44447	HNSC	ICGC	LESTPKRS	DEG_SCF_FBW7_1	0.2778
p.S1149I	SIDM00884	Breast Carcinoma	GDSC	LESTPKRS	DEG_SCF_FBW7_1	0.7341
p.S1149I	ACH-000699	Breast Cancer	CCLE	LESTPKRS	DEG_SCF_FBW7_1	0.7341
p.S1149I	HCC1395	breast	COSMIC	LESTPKRS	DEG_SCF_FBW7_1	0.7341
p.E1153D	SIDM00441	Acute Myeloid Leukemia	GDSC	LESTPKRS	DEG_SCF_FBW7_1	0.2222
p.E1153D	ACH-002273	Leukemia	CCLE	LESTPKRS	DEG_SCF_FBW7_1	0.2222
p.E1153D	ML-2	haematopoietic_and_lymphoid_tissue	COSMIC	LESTPKRS	DEG_SCF_FBW7_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q5JV73	FERM and PDZ domain-containing protein 3	DEG_SCF_FBW7_1	1142:1149	LESTPKRS	FBXW7	0.97	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons