DegronMD

Uniprot ID: Q9UKL3

Source protein: CASP8-associated protein 2

Source gene: CASP8AP2

Class: DEG_APCC_KENBOX_2

Location: 906:910

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9984

ASA_SCORE: 102.7

COIL: 0.6106

CONS_SCORE: 0.8527

DSS_SCORE: 0.598

HELIX: 0.3508

FCONS_SCORE: 1.696

RIG_SCORE: 0.6456

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q902H	SIDM01293	Colorectal Carcinoma	GDSC	NKENQ	DEG_APCC_KENBOX_2	0.2222
p.Y914S	SIDM00994	T-Lymphoblastic Leukemia	GDSC	NKENQ	DEG_APCC_KENBOX_2	0.2222
p.Y914S	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	NKENQ	DEG_APCC_KENBOX_2	0.2222
p.N906S	SIDM00323	B-Cell Non-Hodgkin's Lymphoma	GDSC	NKENQ	DEG_APCC_KENBOX_2	0.5958
p.N906S	SIDM00970	Bladder Carcinoma	GDSC	NKENQ	DEG_APCC_KENBOX_2	0.5958
p.N906S	TK	haematopoietic_and_lymphoid_tissue	COSMIC	NKENQ	DEG_APCC_KENBOX_2	0.5958

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94868	F-BAR and double SH3 domains protein 2	DEG_APCC_KENBOX_2	598:602	NKENQ	APC,CDC20,FZR1	0.6118	More...
Q9UKL3	CASP8-associated protein 2	DEG_APCC_KENBOX_2	906:910	NKENQ	APC,CDC20,FZR1	0.9984	More...
Q9UKT4	F-box only protein 5	DEG_APCC_KENBOX_2	117:121	NKENQ	APC,CDC20,FZR1	0.6005	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons