DegronMD - Q9UKT4(FBXO5)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E111K	TCGA-49-4486	LUAD	TCGA	NKENQ	DEG_APCC_KENBOX_2	117:121	Mutation rewiring degron network	0.1667
p.T110S	TCGA-AY-A71X	COAD	TCGA	NKENQ	DEG_APCC_KENBOX_2	117:121	Mutation rewiring degron network	0.1389
p.F321C	TCGA-BR-6452	STAD	TCGA	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation altering degron motif	0.5996
p.F321C	TCGA-BR-6452	STAD	TCGA	MFRTPLAS	DEG_SCF_FBW7_1	320:327	Mutation altering degron motif	0.5996
p.S157G	TCGA-EO-A22R	UCEC	TCGA	DSGYSS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.1111
p.T110I	TCGA-F4-6570	COAD	TCGA	NKENQ	DEG_APCC_KENBOX_2	117:121	Mutation rewiring degron network	0.1389
p.V328A	TCGA-F5-6814	READ	TCGA	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation altering degron motif	0.6936
p.R114H	TCGA-F5-6814	READ	TCGA	NKENQ	DEG_APCC_KENBOX_2	117:121	Mutation rewiring degron network	0.25
p.S129C	DO474	BLCA	ICGC	NKENQ	DEG_APCC_KENBOX_2	117:121	Mutation rewiring degron network	0.1111
p.E152K	DO225108	BRCA	ICGC	DSGYSS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.25
p.S136T	DO224839	BRCA	ICGC	DSGYSS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.1111
p.S136T	DO52549	BRCA	ICGC	DSGYSS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.1111
p.R312Q	DO222955	BTCA	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.0833
p.R312Q	DO222955	BTCA	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	320:327	Mutation rewiring degron network	0.1111
p.R312Q	DO8119	COAD	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.0833
p.R312Q	DO8119	COAD	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	320:327	Mutation rewiring degron network	0.1111
p.R312Q	DO41331	UCEC	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.0833
p.R312Q	DO41331	UCEC	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	320:327	Mutation rewiring degron network	0.1111
p.F316L	DO6308	CESC	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.1944
p.F316L	DO6308	CESC	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	320:327	Mutation rewiring degron network	0.2222
p.F316L	DO43755	UCEC	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.1944
p.F316L	DO43755	UCEC	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	320:327	Mutation rewiring degron network	0.2222
p.L159F	DO8786	COAD	ICGC	DSGYSS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.0556
p.P137S	DO45513	LUSC	ICGC	DSGYSS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.1389
p.T158A	DO51407	PRAD	ICGC	DSGYSS	DEG_SCF_TRCP1_1	144:149	Mutation rewiring degron network	0.0833
p.R334C	DO43041	UCEC	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.1944
p.R334C	DO43041	UCEC	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	320:327	Mutation rewiring degron network	0.1389
p.R334C	DO42793	UCEC	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.1944
p.R334C	DO42793	UCEC	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	320:327	Mutation rewiring degron network	0.1389
p.R334C	MCC26	skin	COSMIC	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.1944
p.R334C	MCC26	skin	COSMIC	MFRTPLAS	DEG_SCF_FBW7_1	320:327	Mutation rewiring degron network	0.1389
p.E120K	DO41644	UCEC	ICGC	NKENQ	DEG_APCC_KENBOX_2	117:121	Mutation altering degron motif	0.7022
p.S111G	DO42713	UCEC	ICGC	NKENQ	DEG_APCC_KENBOX_2	117:121	Mutation rewiring degron network	0.1667
p.H312R	SIDM00499	Prostate Carcinoma	GDSC	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.0833
p.H312R	SIDM00499	Prostate Carcinoma	GDSC	MFRTPLAS	DEG_SCF_FBW7_1	320:327	Mutation rewiring degron network	0.1111
p.H312R	ACH-000956	Prostate Cancer	CCLE	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.0833
p.H312R	ACH-000956	Prostate Cancer	CCLE	MFRTPLAS	DEG_SCF_FBW7_1	320:327	Mutation rewiring degron network	0.1111
p.H312R	22RV1	prostate	COSMIC	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation rewiring degron network	0.0833
p.H312R	22RV1	prostate	COSMIC	MFRTPLAS	DEG_SCF_FBW7_1	320:327	Mutation rewiring degron network	0.1111
p.K324T	HCC2998	large intestine	COSMIC	FRTPLASVQ	DEG_APCC_DBOX_1	321:329	Mutation altering degron motif	0.7306
p.K324T	HCC2998	large intestine	COSMIC	MFRTPLAS	DEG_SCF_FBW7_1	320:327	Mutation altering degron motif	0.7306
p.D125H	MLMA	haematopoietic and lymphoid tissue	COSMIC	NKENQ	DEG_APCC_KENBOX_2	117:121	Mutation rewiring degron network	0.2222

Kaplan plot for FBXO5 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXO5

UniProt ID: Q9UKT4

Entrez ID: 26271

Protein name: F-box only protein 5 (Early mitotic inhibitor 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXO5 in