DegronMD

Uniprot ID: Q9UKT4

Source protein: F-box only protein 5

Source gene: FBXO5

Class: DEG_SCF_FBW7_1

Location: 320:327

E3 ligase: FBXW7

DEGRON score: 0.9946

ASA_SCORE: 66.575

COIL: 0.5479

CONS_SCORE: 0.571

DSS_SCORE: 0.4275

HELIX: 0.3964

FCONS_SCORE: 1.1683

RIG_SCORE: 0.7907

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K324T	HCC2998	large_intestine	COSMIC	MFRTPLAS	DEG_SCF_FBW7_1	0.7306
p.F321C	TCGA-BR-6452	STAD	TCGA	MFRTPLAS	DEG_SCF_FBW7_1	0.5996
p.F316L	DO6308	CESC	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	0.2222
p.F316L	DO43755	UCEC	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	0.2222
p.R334C	DO43041	UCEC	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	0.1389
p.R334C	DO42793	UCEC	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	0.1389
p.R334C	MCC26	skin	COSMIC	MFRTPLAS	DEG_SCF_FBW7_1	0.1389
p.R312Q	DO222955	BTCA	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	0.1111
p.R312Q	DO8119	COAD	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	0.1111
p.R312Q	DO41331	UCEC	ICGC	MFRTPLAS	DEG_SCF_FBW7_1	0.1111
p.H312R	SIDM00499	Prostate Carcinoma	GDSC	MFRTPLAS	DEG_SCF_FBW7_1	0.1111
p.H312R	ACH-000956	Prostate Cancer	CCLE	MFRTPLAS	DEG_SCF_FBW7_1	0.1111
p.H312R	22RV1	prostate	COSMIC	MFRTPLAS	DEG_SCF_FBW7_1	0.1111

Showing 1 to 13 of 13 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKT4	F-box only protein 5	DEG_SCF_FBW7_1	320:327	MFRTPLAS	FBXW7	0.9946	More...

Showing 1 to 1 of 1 entries

DegronMD: protein-targeted degradation, mutation and drug response to degrons