DegronMD

Uniprot ID: Q9UKT4

Source protein: F-box only protein 5

Source gene: FBXO5

Class: DEG_APCC_KENBOX_2

Location: 117:121

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6005

ASA_SCORE: 96.96

COIL: 0.6574

CONS_SCORE: 0.4372

DSS_SCORE: 0.5677

HELIX: 0.2752

FCONS_SCORE: 1.2602

RIG_SCORE: 0.684

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E111K	TCGA-49-4486	LUAD	TCGA	NKENQ	DEG_APCC_KENBOX_2	0.1667
p.T110S	TCGA-AY-A71X	COAD	TCGA	NKENQ	DEG_APCC_KENBOX_2	0.1389
p.T110I	TCGA-F4-6570	COAD	TCGA	NKENQ	DEG_APCC_KENBOX_2	0.1389
p.R114H	TCGA-F5-6814	READ	TCGA	NKENQ	DEG_APCC_KENBOX_2	0.25
p.S129C	DO474	BLCA	ICGC	NKENQ	DEG_APCC_KENBOX_2	0.1111
p.E120K	DO41644	UCEC	ICGC	NKENQ	DEG_APCC_KENBOX_2	0.7022
p.S111G	DO42713	UCEC	ICGC	NKENQ	DEG_APCC_KENBOX_2	0.1667
p.D125H	MLMA	haematopoietic_and_lymphoid_tissue	COSMIC	NKENQ	DEG_APCC_KENBOX_2	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94868	F-BAR and double SH3 domains protein 2	DEG_APCC_KENBOX_2	598:602	NKENQ	APC,CDC20,FZR1	0.6118	More...
Q9UKL3	CASP8-associated protein 2	DEG_APCC_KENBOX_2	906:910	NKENQ	APC,CDC20,FZR1	0.9984	More...
Q9UKT4	F-box only protein 5	DEG_APCC_KENBOX_2	117:121	NKENQ	APC,CDC20,FZR1	0.6005	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons