DegronMD

Uniprot ID: O94868

Source protein: F-BAR and double SH3 domains protein 2

Source gene: FCHSD2

Class: DEG_APCC_KENBOX_2

Location: 598:602

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6118

ASA_SCORE: 102.86

COIL: 0.6354

CONS_SCORE: 0.4538

DSS_SCORE: 0.3355

HELIX: 0.0186

FCONS_SCORE: 0.9293

RIG_SCORE: 0.7785

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D607N	DO219087	BLCA	ICGC	NKENQ	DEG_APCC_KENBOX_2	0.1944
p.S611C	DO44446	HNSC	ICGC	NKENQ	DEG_APCC_KENBOX_2	0.0833
p.E609K	DO27869	ORCA	ICGC	NKENQ	DEG_APCC_KENBOX_2	0.1389
p.E603D	DO43041	UCEC	ICGC	NKENQ	DEG_APCC_KENBOX_2	0.3056
p.I594L	SIDM01110	Hepatocellular Carcinoma	GDSC	NKENQ	DEG_APCC_KENBOX_2	0.2222
p.I594L	SK-HEP-1	liver	COSMIC	NKENQ	DEG_APCC_KENBOX_2	0.2222
p.H589Y	ACH-000997	Colon/Colorectal Cancer	CCLE	NKENQ	DEG_APCC_KENBOX_2	0.0833
p.H589Y	HCT-15	large_intestine	COSMIC	NKENQ	DEG_APCC_KENBOX_2	0.0833
p.P591L	ES-2	ovary	COSMIC	NKENQ	DEG_APCC_KENBOX_2	0.1389
p.P612S	CHSA0011	bone	COSMIC	NKENQ	DEG_APCC_KENBOX_2	0.0556
p.P612S	SK-PN-DW	bone	COSMIC	NKENQ	DEG_APCC_KENBOX_2	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94868	F-BAR and double SH3 domains protein 2	DEG_APCC_KENBOX_2	598:602	NKENQ	APC,CDC20,FZR1	0.6118	More...
Q9UKL3	CASP8-associated protein 2	DEG_APCC_KENBOX_2	906:910	NKENQ	APC,CDC20,FZR1	0.9984	More...
Q9UKT4	F-box only protein 5	DEG_APCC_KENBOX_2	117:121	NKENQ	APC,CDC20,FZR1	0.6005	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons