DegronMD

Uniprot ID: Q9UKT4

Source protein: F-box only protein 5

Source gene: FBXO5

Class: DEG_SCF_TRCP1_1

Location: 144:149

E3 ligase: BTRC

DEGRON score: 0.9993

ASA_SCORE: 61.9333

COIL: 0.7582

CONS_SCORE: 0.5348

DSS_SCORE: 0.3984

HELIX: 0.1653

FCONS_SCORE: 1.3862

RIG_SCORE: 0.6886

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S157G	TCGA-EO-A22R	UCEC	TCGA	DSGYSS	DEG_SCF_TRCP1_1	0.1111
p.E152K	DO225108	BRCA	ICGC	DSGYSS	DEG_SCF_TRCP1_1	0.25
p.S136T	DO224839	BRCA	ICGC	DSGYSS	DEG_SCF_TRCP1_1	0.1111
p.S136T	DO52549	BRCA	ICGC	DSGYSS	DEG_SCF_TRCP1_1	0.1111
p.L159F	DO8786	COAD	ICGC	DSGYSS	DEG_SCF_TRCP1_1	0.0556
p.P137S	DO45513	LUSC	ICGC	DSGYSS	DEG_SCF_TRCP1_1	0.1389
p.T158A	DO51407	PRAD	ICGC	DSGYSS	DEG_SCF_TRCP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKT4	F-box only protein 5	DEG_SCF_TRCP1_1	144:149	DSGYSS	BTRC	0.9993	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons