DegronMD

Uniprot ID: Q9UKT4

Source protein: F-box only protein 5

Source gene: FBXO5

Class: DEG_APCC_DBOX_1

Location: 321:329

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9983

ASA_SCORE: 66.8111

COIL: 0.5013

CONS_SCORE: 0.6003

DSS_SCORE: 0.4156

HELIX: 0.4496

FCONS_SCORE: 1.2878

RIG_SCORE: 0.7768

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F321C	TCGA-BR-6452	STAD	TCGA	FRTPLASVQ	DEG_APCC_DBOX_1	0.5996
p.V328A	TCGA-F5-6814	READ	TCGA	FRTPLASVQ	DEG_APCC_DBOX_1	0.6936
p.R312Q	DO222955	BTCA	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	0.0833
p.R312Q	DO8119	COAD	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	0.0833
p.R312Q	DO41331	UCEC	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	0.0833
p.F316L	DO6308	CESC	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	0.1944
p.F316L	DO43755	UCEC	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	0.1944
p.R334C	DO43041	UCEC	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	0.1944
p.R334C	DO42793	UCEC	ICGC	FRTPLASVQ	DEG_APCC_DBOX_1	0.1944
p.R334C	MCC26	skin	COSMIC	FRTPLASVQ	DEG_APCC_DBOX_1	0.1944
p.H312R	SIDM00499	Prostate Carcinoma	GDSC	FRTPLASVQ	DEG_APCC_DBOX_1	0.0833
p.H312R	ACH-000956	Prostate Cancer	CCLE	FRTPLASVQ	DEG_APCC_DBOX_1	0.0833
p.H312R	22RV1	prostate	COSMIC	FRTPLASVQ	DEG_APCC_DBOX_1	0.0833
p.K324T	HCC2998	large_intestine	COSMIC	FRTPLASVQ	DEG_APCC_DBOX_1	0.7306

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKT4	F-box only protein 5	DEG_APCC_DBOX_1	321:329	FRTPLASVQ	APC,CDC20,FZR1	0.9983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons