DegronMD

Uniprot ID: Q9UKL3

Source protein: CASP8-associated protein 2

Source gene: CASP8AP2

Class: DEG_SCF_FBW7_2

Location: 1259:1265

E3 ligase: FBXW7

DEGRON score: 0.9771

ASA_SCORE: 96.2

COIL: 0.9326

CONS_SCORE: 0.4103

DSS_SCORE: 0.6275

HELIX: 0.0404

FCONS_SCORE: 1.0474

RIG_SCORE: 0.5892

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R1252C	SIDM00990	Non-Small Cell Lung Carcinoma	GDSC	PSTPKSE	DEG_SCF_FBW7_2	0.1389
p.H1257Q	SIDM00530	Esophageal Carcinoma	GDSC	PSTPKSE	DEG_SCF_FBW7_2	0.2778
p.C1258S	SIDM00530	Esophageal Carcinoma	GDSC	PSTPKSE	DEG_SCF_FBW7_2	0.3056
p.E1255G	SIDM00898	Breast Carcinoma	GDSC	PSTPKSE	DEG_SCF_FBW7_2	0.2222
p.E1255G	AU565	breast	COSMIC	PSTPKSE	DEG_SCF_FBW7_2	0.2222
p.E1273D	SIDM00839	Colorectal Carcinoma	GDSC	PSTPKSE	DEG_SCF_FBW7_2	0.1111
p.E1273D	LoVo	large_intestine	COSMIC	PSTPKSE	DEG_SCF_FBW7_2	0.1111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKL3	CASP8-associated protein 2	DEG_SCF_FBW7_2	1259:1265	PSTPKSE	FBXW7	0.9771	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons