DegronMD

Uniprot ID: Q9UKL3

Source protein: CASP8-associated protein 2

Source gene: CASP8AP2

Class: DEG_SCF_FBW7_2

Location: 790:797

E3 ligase: FBXW7

DEGRON score: 0.9285

ASA_SCORE: 97.6125

COIL: 0.8434

CONS_SCORE: 0.4174

DSS_SCORE: 0.3381

HELIX: 0.0381

FCONS_SCORE: 0.9045

RIG_SCORE: 0.7775

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P805S	SIDM00945	Colorectal Carcinoma	GDSC	VIVTPLVE	DEG_SCF_FBW7_2	0.1111
p.P805S	CL-34	large_intestine	COSMIC	VIVTPLVE	DEG_SCF_FBW7_2	0.1111
p.I791R	SIDM01343	Gastric Carcinoma	GDSC	VIVTPLVE	DEG_SCF_FBW7_2	0.6991

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKL3	CASP8-associated protein 2	DEG_SCF_FBW7_2	790:797	VIVTPLVE	FBXW7	0.9285	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons