DegronMD

Uniprot ID: P51826

Source protein: AF4/FMR2 family member 3

Source gene: AFF3

Class: DEG_SIAH_1

Location: 230:238

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.96

ASA_SCORE: 104.9778

COIL: 0.9393

CONS_SCORE: 0.3714

DSS_SCORE: 0.6903

HELIX: 0.0282

FCONS_SCORE: 0.8162

RIG_SCORE: 0.7062

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H236P	TCGA-05-4405	LUAD	TCGA	KPTAYVRPM	DEG_SIAH_1	0.7694
p.A229T	TCGA-A5-A0G2	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.3056
p.A229T	TCGA-DX-A6YX	SARC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.3056
p.A229T	DO220013	SARC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.3056
p.A229T	DO41235	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.3056
p.A228V	TCGA-EO-A22R	UCEC	TCGA	KPTAYVRPM	DEG_SIAH_1	0.2778
p.S232N	TCGA-XK-AAIW	PRAD	TCGA	KPTAYVRPM	DEG_SIAH_1	0.7069
p.S232N	DO51407	PRAD	ICGC	KPTAYVRPM	DEG_SIAH_1	0.7069
p.A233V	DO227978	COCA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.6936
p.A233V	DO232224	PBCA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.6936
p.A233V	DO41235	UCEC	ICGC	KPTAYVRPM	DEG_SIAH_1	0.6936
p.P243L	DO222714	MELA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.1944
p.R236K	DO37406	SKCM	ICGC	KPTAYVRPM	DEG_SIAH_1	0.6126
p.T232A	DO50119	STAD	ICGC	KPTAYVRPM	DEG_SIAH_1	0.6028
p.T232A	ACH-000362	Leukemia	CCLE	KPTAYVRPM	DEG_SIAH_1	0.6028
p.T232A	MOLM-13	haematopoietic_and_lymphoid_tissue	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.6028
p.P231L	DO231312	THCA	ICGC	KPTAYVRPM	DEG_SIAH_1	0.7582
p.T220I	SIDM00516	Melanoma	GDSC	KPTAYVRPM	DEG_SIAH_1	0.0556
p.T220I	MZ7-mel	skin	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.0556
p.S244F	SIDM01159	Other Sarcomas	GDSC	KPTAYVRPM	DEG_SIAH_1	0.1667
p.S244F	SW872	soft_tissue	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.1667
p.E247V	ACH-000870	Lung Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	0.0833
p.A244S	ACH-000871	Lung Cancer	CCLE	KPTAYVRPM	DEG_SIAH_1	0.1667
p.A244S	NCI-H510A	lung	COSMIC	KPTAYVRPM	DEG_SIAH_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons