DegronMD - Q8TBP0(TBC1D16)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R250C	TCGA-98-A53B	LUSC	TCGA	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.8301
p.R250C	DO52023	LUSC	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.8301
p.G26S	TCGA-A6-6781	COAD	TCGA	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.3056
p.G26S	DO8447	COAD	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.3056
p.G26S	DO222765	COCA	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.3056
p.S15T	TCGA-AA-A01R	COAD	TCGA	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.25
p.S15T	DO7934	COAD	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.25
p.D266H	TCGA-AX-A3FX	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.3056
p.D266H	TCGA-AX-A3FX	UCEC	TCGA	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.0556
p.D266H	TCGA-BP-4986	KIRC	TCGA	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.3056
p.D266H	TCGA-BP-4986	KIRC	TCGA	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.0556
p.D266H	DO20032	KIRC	ICGC	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.3056
p.D266H	DO20032	KIRC	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.0556
p.D266H	DO42801	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.3056
p.D266H	DO42801	UCEC	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.0556
p.A145G	TCGA-B5-A1MR	UCEC	TCGA	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.1667
p.A145G	DO41758	UCEC	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.1667
p.A244V	TCGA-B5-A3FA	UCEC	TCGA	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1667
p.A244V	DO52402	UCEC	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1667
p.T128M	TCGA-B5-A3FC	UCEC	TCGA	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.2222
p.T128M	DO234278	ESAD	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.2222
p.T128M	DO41871	UCEC	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.2222
p.P262Q	TCGA-BJ-A0ZC	THCA	TCGA	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.5924
p.P262Q	DO38938	THCA	ICGC	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.5924
p.R8C	TCGA-BR-8487	STAD	TCGA	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.0556
p.R8C	DO47867	STAD	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.0556
p.R8C	SIDM00018	Acute Myeloid Leukemia	GDSC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.0556
p.R8C	SIDM01033	Bladder Carcinoma	GDSC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.0556
p.R8C	ACH-000486	Bladder Cancer	CCLE	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.0556
p.R8C	ACH-001605	Brain Cancer	CCLE	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.0556
p.S31F	TCGA-C5-A905	CESC	TCGA	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.1667
p.S31F	DO49918	CESC	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.1667
p.S265F	TCGA-CD-8527	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.7982
p.S265F	DO47739	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.7982
p.G251S	TCGA-D5-6927	COAD	TCGA	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.5882
p.G251S	DO223419	CLLE	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.5882
p.G251S	DO10332	COAD	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.5882
p.G23S	TCGA-D7-A74A	STAD	TCGA	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation altering degron motif	0.5882
p.G23S	DO50123	STAD	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation altering degron motif	0.5882
p.P104L	TCGA-EE-A2MR	SKCM	TCGA	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.3056
p.P104L	DO233878	GACA	ICGC	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.3056
p.P104L	DO37819	SKCM	ICGC	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.3056
p.P127L	TCGA-EE-A2MS	SKCM	TCGA	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.1944
p.P127L	DO37567	SKCM	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.1944
p.N275S	TCGA-EY-A1GP	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0556
p.N275S	DO41265	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.0556
p.D266N	TCGA-HU-A4GN	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.3056
p.D266N	TCGA-HU-A4GN	STAD	TCGA	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.0556
p.D266N	DO47833	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.3056
p.D266N	DO47833	STAD	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.0556
p.A94V	TCGA-HU-A4GQ	STAD	TCGA	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.2222
p.A94V	DO47767	STAD	ICGC	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.2222
p.R110C	TCGA-L5-A4OE	ESCA	TCGA	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.1389
p.S122F	TCGA-RP-A695	SKCM	TCGA	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.0556
p.S122F	DO51270	SKCM	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.0556
p.P136R	DO225140	BRCA	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation altering degron motif	0.7512
p.Q90K	DO218254	BRCA	ICGC	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.1111
p.T262M	DO233205	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.7423
p.V271M	DO233700	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1667
p.R131L	DO228813	LICA	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.3056
p.E92K	DO228944	LICA	ICGC	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.1667
p.A267D	DO228974	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.2778
p.R131W	DO229053	LICA	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.3056
p.D16N	DO229058	LICA	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.2778
p.R110L	DO231598	LINC	ICGC	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.1389
p.R110L	DO231553	LINC	ICGC	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.1389
p.R8L	DO25797	LUAD	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.0556
p.P125L	DO220903	MELA	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.1389
p.TP135TS	DO222413	MELA	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation altering degron motif	0.7116
p.T21I	DO222843	MELA	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation altering degron motif	0.7078
p.G268C	DO34680	PACA	ICGC	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.25
p.S29P	DO229242	THCA	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.2222
p.G28R	SIDM01314	Colorectal Carcinoma	GDSC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.25
p.R270W	SIDM01016	T-Lymphoblastic Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1944
p.R270W	SIDM01263	T-Lymphoblastic Leukemia	GDSC	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1944
p.R270W	Jurkat	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation rewiring degron network	0.1944
p.P30S	SIDM00422	Hodgkin's Lymphoma	GDSC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.1944
p.P30S	ACH-001203	Lymphoma	CCLE	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation rewiring degron network	0.1944
p.S252F	SIDM00545	Melanoma	GDSC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.6871
p.S252F	ACH-000987	Skin Cancer	CCLE	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.6871
p.S252F	Mewo	skin	COSMIC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation altering degron motif	0.6871
p.R96L	SIDM00234	Other Solid Cancers	GDSC	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.2778
p.R96L	ACH-002201	Cervical Cancer	CCLE	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.2778
p.R96L	TC-YIK	cervix	COSMIC	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.2778
p.R131Q	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.3056
p.R131Q	ACH-002301	Lymphoma	CCLE	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.3056
p.R131Q	RF-48	stomach	COSMIC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.3056
p.A244T	SIDM00694	Other Solid Cancers	GDSC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1667
p.A245V	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1944
p.A245V	ROS-50	haematopoietic and lymphoid tissue	COSMIC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	250:256	Mutation rewiring degron network	0.1944
p.S122A	ACH-000879	Endometrial/Uterine Cancer	CCLE	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.0556
p.S122A	MFE-296	endometrium	COSMIC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.0556
p.P262L	ACH-002046	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	261:265	Mutation altering degron motif	0.6471
p.S22F	MCC13	skin	COSMIC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation altering degron motif	0.7982
p.N147D	EN	endometrium	COSMIC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.1111
p.N148D	EN	endometrium	COSMIC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation rewiring degron network	0.0833
p.N134D	EN	endometrium	COSMIC	PTLTPKDE	DEG_SCF_FBW7_2	132:139	Mutation altering degron motif	0.6932
p.R94W	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.2222
p.S21F	MCC13	skin	COSMIC	LTLTPGGS	DEG_SCF_FBW7_1	18:25	Mutation altering degron motif	0.7982
p.R93W	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	ITPESS	DEG_SCF_FBW7_1	98:103	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

TBC1D16

UniProt ID: Q8TBP0

Entrez ID: 125058

Protein name: TBC1 domain family member 16

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for TBC1D16 in