DegronMD

Uniprot ID: Q8TBP0

Source protein: TBC1 domain family member 16

Source gene: TBC1D16

Class: DEG_SCF_FBW7_2

Location: 132:139

E3 ligase: FBXW7

DEGRON score: 0.9556

ASA_SCORE: 83.8125

COIL: 0.863

CONS_SCORE: 0.365

DSS_SCORE: 0.6309

HELIX: 0.0755

FCONS_SCORE: 1.0629

RIG_SCORE: 0.6866

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A145G	TCGA-B5-A1MR	UCEC	TCGA	PTLTPKDE	DEG_SCF_FBW7_2	0.1667
p.A145G	DO41758	UCEC	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	0.1667
p.T128M	TCGA-B5-A3FC	UCEC	TCGA	PTLTPKDE	DEG_SCF_FBW7_2	0.2222
p.T128M	DO234278	ESAD	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	0.2222
p.T128M	DO41871	UCEC	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	0.2222
p.P127L	TCGA-EE-A2MS	SKCM	TCGA	PTLTPKDE	DEG_SCF_FBW7_2	0.1944
p.P127L	DO37567	SKCM	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	0.1944
p.S122F	TCGA-RP-A695	SKCM	TCGA	PTLTPKDE	DEG_SCF_FBW7_2	0.0556
p.S122F	DO51270	SKCM	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	0.0556
p.P136R	DO225140	BRCA	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	0.7512
p.R131L	DO228813	LICA	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	0.3056
p.R131W	DO229053	LICA	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	0.3056
p.P125L	DO220903	MELA	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	0.1389
p.TP135TS	DO222413	MELA	ICGC	PTLTPKDE	DEG_SCF_FBW7_2	0.7116
p.R131Q	SIDM01092	B-Cell Non-Hodgkin's Lymphoma	GDSC	PTLTPKDE	DEG_SCF_FBW7_2	0.3056
p.R131Q	ACH-002301	Lymphoma	CCLE	PTLTPKDE	DEG_SCF_FBW7_2	0.3056
p.R131Q	RF-48	stomach	COSMIC	PTLTPKDE	DEG_SCF_FBW7_2	0.3056
p.S122A	ACH-000879	Endometrial/Uterine Cancer	CCLE	PTLTPKDE	DEG_SCF_FBW7_2	0.0556
p.S122A	MFE-296	endometrium	COSMIC	PTLTPKDE	DEG_SCF_FBW7_2	0.0556
p.N147D	EN	endometrium	COSMIC	PTLTPKDE	DEG_SCF_FBW7_2	0.1111
p.N148D	EN	endometrium	COSMIC	PTLTPKDE	DEG_SCF_FBW7_2	0.0833
p.N134D	EN	endometrium	COSMIC	PTLTPKDE	DEG_SCF_FBW7_2	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBP0	TBC1 domain family member 16	DEG_SCF_FBW7_2	132:139	PTLTPKDE	FBXW7	0.9556	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons