DegronMD

Uniprot ID: Q8TBP0

Source protein: TBC1 domain family member 16

Source gene: TBC1D16

Class: DEG_SCF_FBW7_1

Location: 98:103

E3 ligase: FBXW7

DEGRON score: 0.999

ASA_SCORE: 76.5667

COIL: 0.8528

CONS_SCORE: 0.4355

DSS_SCORE: 0.5846

HELIX: 0.0788

FCONS_SCORE: 1.0104

RIG_SCORE: 0.6924

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P104L	TCGA-EE-A2MR	SKCM	TCGA	ITPESS	DEG_SCF_FBW7_1	0.3056
p.P104L	DO233878	GACA	ICGC	ITPESS	DEG_SCF_FBW7_1	0.3056
p.P104L	DO37819	SKCM	ICGC	ITPESS	DEG_SCF_FBW7_1	0.3056
p.A94V	TCGA-HU-A4GQ	STAD	TCGA	ITPESS	DEG_SCF_FBW7_1	0.2222
p.A94V	DO47767	STAD	ICGC	ITPESS	DEG_SCF_FBW7_1	0.2222
p.R110C	TCGA-L5-A4OE	ESCA	TCGA	ITPESS	DEG_SCF_FBW7_1	0.1389
p.Q90K	DO218254	BRCA	ICGC	ITPESS	DEG_SCF_FBW7_1	0.1111
p.E92K	DO228944	LICA	ICGC	ITPESS	DEG_SCF_FBW7_1	0.1667
p.R110L	DO231598	LINC	ICGC	ITPESS	DEG_SCF_FBW7_1	0.1389
p.R110L	DO231553	LINC	ICGC	ITPESS	DEG_SCF_FBW7_1	0.1389
p.R96L	SIDM00234	Other Solid Cancers	GDSC	ITPESS	DEG_SCF_FBW7_1	0.2778
p.R96L	ACH-002201	Cervical Cancer	CCLE	ITPESS	DEG_SCF_FBW7_1	0.2778
p.R96L	TC-YIK	cervix	COSMIC	ITPESS	DEG_SCF_FBW7_1	0.2778
p.R94W	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ITPESS	DEG_SCF_FBW7_1	0.2222
p.R93W	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	ITPESS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBP0	TBC1 domain family member 16	DEG_SCF_FBW7_1	98:103	ITPESS	FBXW7	0.999	More...
Q5JV73	FERM and PDZ domain-containing protein 3	DEG_SCF_FBW7_1	795:800	ITPESS	FBXW7	0.9064	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons