DegronMD

Uniprot ID: Q8TBP0

Source protein: TBC1 domain family member 16

Source gene: TBC1D16

Class: DEG_SCF_FBW7_1

Location: 18:25

E3 ligase: FBXW7

DEGRON score: 0.9958

ASA_SCORE: 75.9

COIL: 0.8808

CONS_SCORE: 0.3963

DSS_SCORE: 0.4931

HELIX: 0.0748

FCONS_SCORE: 0.8783

RIG_SCORE: 0.6387

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G26S	TCGA-A6-6781	COAD	TCGA	LTLTPGGS	DEG_SCF_FBW7_1	0.3056
p.G26S	DO8447	COAD	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	0.3056
p.G26S	DO222765	COCA	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	0.3056
p.S15T	TCGA-AA-A01R	COAD	TCGA	LTLTPGGS	DEG_SCF_FBW7_1	0.25
p.S15T	DO7934	COAD	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	0.25
p.R8C	TCGA-BR-8487	STAD	TCGA	LTLTPGGS	DEG_SCF_FBW7_1	0.0556
p.R8C	DO47867	STAD	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	0.0556
p.R8C	SIDM00018	Acute Myeloid Leukemia	GDSC	LTLTPGGS	DEG_SCF_FBW7_1	0.0556
p.R8C	SIDM01033	Bladder Carcinoma	GDSC	LTLTPGGS	DEG_SCF_FBW7_1	0.0556
p.R8C	ACH-000486	Bladder Cancer	CCLE	LTLTPGGS	DEG_SCF_FBW7_1	0.0556
p.R8C	ACH-001605	Brain Cancer	CCLE	LTLTPGGS	DEG_SCF_FBW7_1	0.0556
p.S31F	TCGA-C5-A905	CESC	TCGA	LTLTPGGS	DEG_SCF_FBW7_1	0.1667
p.S31F	DO49918	CESC	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	0.1667
p.G23S	TCGA-D7-A74A	STAD	TCGA	LTLTPGGS	DEG_SCF_FBW7_1	0.5882
p.G23S	DO50123	STAD	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	0.5882
p.D16N	DO229058	LICA	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	0.2778
p.R8L	DO25797	LUAD	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	0.0556
p.T21I	DO222843	MELA	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	0.7078
p.S29P	DO229242	THCA	ICGC	LTLTPGGS	DEG_SCF_FBW7_1	0.2222
p.G28R	SIDM01314	Colorectal Carcinoma	GDSC	LTLTPGGS	DEG_SCF_FBW7_1	0.25
p.P30S	SIDM00422	Hodgkin's Lymphoma	GDSC	LTLTPGGS	DEG_SCF_FBW7_1	0.1944
p.P30S	ACH-001203	Lymphoma	CCLE	LTLTPGGS	DEG_SCF_FBW7_1	0.1944
p.S22F	MCC13	skin	COSMIC	LTLTPGGS	DEG_SCF_FBW7_1	0.7982
p.S21F	MCC13	skin	COSMIC	LTLTPGGS	DEG_SCF_FBW7_1	0.7982

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBP0	TBC1 domain family member 16	DEG_SCF_FBW7_1	18:25	LTLTPGGS	FBXW7	0.9958	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons