DegronMD

Uniprot ID: Q8TBP0

Source protein: TBC1 domain family member 16

Source gene: TBC1D16

Class: LIG_APCC_ABBAyCdc20_2

Location: 250:256

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9573

ASA_SCORE: 79.3571

COIL: 0.6574

CONS_SCORE: 0.4091

DSS_SCORE: 0.4733

HELIX: 0.1827

FCONS_SCORE: 1.0418

RIG_SCORE: 0.6851

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R250C	TCGA-98-A53B	LUSC	TCGA	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.8301
p.R250C	DO52023	LUSC	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.8301
p.D266H	TCGA-AX-A3FX	UCEC	TCGA	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D266H	TCGA-BP-4986	KIRC	TCGA	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D266H	DO20032	KIRC	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D266H	DO42801	UCEC	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.A244V	TCGA-B5-A3FA	UCEC	TCGA	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A244V	DO52402	UCEC	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.G251S	TCGA-D5-6927	COAD	TCGA	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.5882
p.G251S	DO223419	CLLE	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.5882
p.G251S	DO10332	COAD	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.5882
p.D266N	TCGA-HU-A4GN	STAD	TCGA	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.D266N	DO47833	STAD	ICGC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.0556
p.S252F	SIDM00545	Melanoma	GDSC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.6871
p.S252F	ACH-000987	Skin Cancer	CCLE	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.6871
p.S252F	Mewo	skin	COSMIC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.6871
p.A244T	SIDM00694	Other Solid Cancers	GDSC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.1667
p.A245V	SIDM00415	B-Cell Non-Hodgkin's Lymphoma	GDSC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.1944
p.A245V	ROS-50	haematopoietic_and_lymphoid_tissue	COSMIC	RGSVFLE	LIG_APCC_ABBAyCdc20_2	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TBP0	TBC1 domain family member 16	LIG_APCC_ABBAyCdc20_2	250:256	RGSVFLE	APC,CDC20,FZR1	0.9573	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons