DegronMD - O94979(SEC31A)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G975R	TCGA-AA-3819	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.0556
p.G975R	DO10590	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.0556
p.P908H	TCGA-D3-A2JO	SKCM	TCGA	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation altering degron motif	0.7694
p.P908H	DO47619	SKCM	ICGC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation altering degron motif	0.7694
p.G957R	TCGA-F5-6814	READ	TCGA	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.2222
p.G957R	DO36556	READ	ICGC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.2222
p.S923Y	TCGA-HU-A4H5	STAD	TCGA	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.0833
p.S923Y	DO47727	STAD	ICGC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.0833
p.P958L	DO233104	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.25
p.T973K	DO229031	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.1111
p.F970I	DO26665	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.1944
p.P958A	DO46374	OV	ICGC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.25
p.P911S	DO229462	SKCA	ICGC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation altering degron motif	0.6752
p.P911S	SIDM00516	Melanoma	GDSC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation altering degron motif	0.6752
p.P911S	ACH-002166	Skin Cancer	CCLE	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation altering degron motif	0.6752
p.P911S	MZ7-mel	skin	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation altering degron motif	0.6752
p.P958H	DO223282	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.25
p.I954N	DO42280	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.1389
p.N905D	SIDM00864	Cervical Carcinoma	GDSC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.25
p.N905D	ACH-001341	Cervical Cancer	CCLE	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.25
p.N905D	DoTc2-4510	cervix	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.25
p.G972E	SIDM00673	Breast Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.1389
p.G972E	ACH-000668	Breast Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.1389
p.G972E	HCC70	breast	COSMIC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.1389
p.G912D	SNU-1040	large intestine	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation altering degron motif	0.7198
p.H903Y	KMS-11	haematopoietic and lymphoid tissue	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.1944
p.G951D	SNU-1040	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.0556
p.A923S	RVH-421	skin	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.0833
p.A959S	RVH-421	skin	COSMIC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.2778
p.F916V	NCI-N87	stomach	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.2778
p.P913S	LS-180	large intestine	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation altering degron motif	0.6752
p.P973L	C3A	liver	COSMIC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.1111
p.P908T	LC4-1	haematopoietic and lymphoid tissue	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation altering degron motif	0.7031
p.P906S	MZ7-mel	skin	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.2778
p.K957T	IM-9	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.2222
p.M954V	PF-382	haematopoietic and lymphoid tissue	COSMIC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.1389
p.N900D	DoTc2-4510	cervix	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.1111
p.P907S	KYSE-150	oesophagus	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation rewiring degron network	0.3056
p.G967E	HCC70	breast	COSMIC	PPSSS	DEG_SPOP_SBC_1	961:965	Mutation rewiring degron network	0.2778
p.P913L	C3A	liver	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation altering degron motif	0.7582
p.P913L	DBTRG-05MG	central nervous system	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	908:914	Mutation altering degron motif	0.7582

Kaplan plot for SEC31A in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEC31A

UniProt ID: O94979

Entrez ID: 22872

Protein name: Protein transport protein Sec31A (ABP125) (ABP130) (SEC31-like protein 1) (SEC31-related protein A) (Web1-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEC31A in