DegronMD

Uniprot ID: O94979

Source protein: Protein transport protein Sec31A

Source gene: SEC31A

Class: DEG_SCF_FBW7_1

Location: 908:914

E3 ligase: FBXW7

DEGRON score: 0.9772

ASA_SCORE: 75.1429

COIL: 0.9527

CONS_SCORE: 0.2552

DSS_SCORE: 0.501

HELIX: 0.016

FCONS_SCORE: 0.9728

RIG_SCORE: 0.7055

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P908H	TCGA-D3-A2JO	SKCM	TCGA	PNTPYIS	DEG_SCF_FBW7_1	0.7694
p.P908H	DO47619	SKCM	ICGC	PNTPYIS	DEG_SCF_FBW7_1	0.7694
p.S923Y	TCGA-HU-A4H5	STAD	TCGA	PNTPYIS	DEG_SCF_FBW7_1	0.0833
p.S923Y	DO47727	STAD	ICGC	PNTPYIS	DEG_SCF_FBW7_1	0.0833
p.P911S	DO229462	SKCA	ICGC	PNTPYIS	DEG_SCF_FBW7_1	0.6752
p.P911S	SIDM00516	Melanoma	GDSC	PNTPYIS	DEG_SCF_FBW7_1	0.6752
p.P911S	ACH-002166	Skin Cancer	CCLE	PNTPYIS	DEG_SCF_FBW7_1	0.6752
p.P911S	MZ7-mel	skin	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	0.6752
p.N905D	SIDM00864	Cervical Carcinoma	GDSC	PNTPYIS	DEG_SCF_FBW7_1	0.25
p.N905D	ACH-001341	Cervical Cancer	CCLE	PNTPYIS	DEG_SCF_FBW7_1	0.25
p.N905D	DoTc2-4510	cervix	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	0.25
p.G912D	SNU-1040	large_intestine	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	0.7198
p.H903Y	KMS-11	haematopoietic_and_lymphoid_tissue	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	0.1944
p.A923S	RVH-421	skin	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	0.0833
p.F916V	NCI-N87	stomach	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	0.2778
p.P913S	LS-180	large_intestine	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	0.6752
p.P908T	LC4-1	haematopoietic_and_lymphoid_tissue	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	0.7031
p.P906S	MZ7-mel	skin	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	0.2778
p.N900D	DoTc2-4510	cervix	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	0.1111
p.P907S	KYSE-150	oesophagus	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	0.3056
p.P913L	C3A	liver	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	0.7582
p.P913L	DBTRG-05MG	central_nervous_system	COSMIC	PNTPYIS	DEG_SCF_FBW7_1	0.7582

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94979	Protein transport protein Sec31A	DEG_SCF_FBW7_1	908:914	PNTPYIS	FBXW7	0.9772	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons