DegronMD

Uniprot ID: Q96EV8

Source protein: Dysbindin

Source gene: DTNBP1

Class: DEG_SPOP_SBC_1

Location: 295:299

E3 ligase: SPOP

DEGRON score: 0.9933

ASA_SCORE: 87.44

COIL: 0.9552

CONS_SCORE: 0.3407

DSS_SCORE: 0.6901

HELIX: 0.0316

FCONS_SCORE: 1.0214

RIG_SCORE: 0.5453

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S297C	TCGA-4Z-AA87	BLCA	TCGA	PPSSS	DEG_SPOP_SBC_1	0.8652
p.P296L	TCGA-AJ-A3EL	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	0.6471
p.S298C	DO218990	BLCA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.7541
p.E295K	DO785	BLCA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.7022
p.P299A	DO1990	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.7503
p.P289T	DO8463	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	0.1667
p.R294C	DO22237	LGG	ICGC	PPSSS	DEG_SPOP_SBC_1	0.3056
p.P290Q	DO228985	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.1944
p.P286T	DO229019	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.0833
p.P299Q	DO229025	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.7035
p.C303R	DO23108	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	0.6667
p.C303R	DO45041	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	0.6667
p.K291N	DO26510	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	0.2222
p.D304N	DO232761	PBCA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.1944
p.P297L	DO41542	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P296S	SIDM01117	Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.5641
p.P296S	SIDM00844	Burkitt's Lymphoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.5641
p.P295L	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.P295L	KYSE-410	oesophagus	COSMIC	PPSSS	DEG_SPOP_SBC_1	0.7582
p.S288P	SIDM00333	Endometrial Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.1389
p.S288P	MFE-319	endometrium	COSMIC	PPSSS	DEG_SPOP_SBC_1	0.1389
p.T295S	NCI-H82	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	0.7116
p.D294Y	IM-95	stomach	COSMIC	PPSSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
C9JLW8	Mapk-regulated corepressor-interacting protein 1	DEG_SPOP_SBC_1	22:26	PPSSS	SPOP	0.978	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	252:256	PPSSS	SPOP	0.9757	More...
O14976	Cyclin-G-associated kinase	DEG_SPOP_SBC_1	781:785	PPSSS	SPOP	0.9989	More...
O15534	Period circadian protein homolog 1	DEG_SPOP_SBC_1	100:104	PPSSS	SPOP	0.997	More...
O43516	WAS/WASL-interacting protein family member 1	DEG_SPOP_SBC_1	322:326	PPSSS	SPOP	0.9012	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	482:486	PPSSS	SPOP	0.8891	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	82:86	PPSSS	SPOP	0.9981	More...
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1285:1289	PPSSS	SPOP	0.8542	More...
O94979	Protein transport protein Sec31A	DEG_SPOP_SBC_1	961:965	PPSSS	SPOP	0.9968	More...
O94983	Calmodulin-binding transcription activator 2	DEG_SPOP_SBC_1	827:831	PPSSS	SPOP	0.9934	More...
O95243	Methyl-CpG-binding domain protein 4	DEG_SPOP_SBC_1	191:195	PPSSS	SPOP	0.967	More...
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	DEG_SPOP_SBC_1	829:833	PPSSS	SPOP	0.9905	More...
O95714	E3 ubiquitin-protein ligase HERC2	DEG_SPOP_SBC_1	2632:2636	PPSSS	SPOP	0.9299	More...
O95948	One cut domain family member 2	DEG_SPOP_SBC_1	315:319	PPSSS	SPOP	0.9973	More...
P04150	Glucocorticoid receptor	DEG_SPOP_SBC_1	405:409	PPSSS	SPOP	0.8508	More...
P04275	von Willebrand factor	DEG_SPOP_SBC_1	205:209	PPSSS	SPOP	0.9077	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2307:2311	PPSSS	SPOP	0.9266	More...
P49356	Protein farnesyltransferase subunit beta	DEG_SPOP_SBC_1	12:16	PPSSS	SPOP	0.9534	More...
P50402	Emerin	DEG_SPOP_SBC_1	50:54	PPSSS	SPOP	0.9872	More...
P50749	Ras association domain-containing protein 2	DEG_SPOP_SBC_1	80:84	PPSSS	SPOP	0.9712	More...
P51813	Cytoplasmic tyrosine-protein kinase BMX	DEG_SPOP_SBC_1	206:210	PPSSS	SPOP	0.9857	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	444:448	PPSSS	SPOP	0.8502	More...
P53779	Mitogen-activated protein kinase 10	DEG_SPOP_SBC_1	428:432	PPSSS	SPOP	0.9915	More...
P78426	Homeobox protein Nkx-6.1	DEG_SPOP_SBC_1	47:51	PPSSS	SPOP	0.9986	More...
Q08289	Voltage-dependent L-type calcium channel subunit beta-2	DEG_SPOP_SBC_1	466:470	PPSSS	SPOP	0.9947	More...
Q10587	Thyrotroph embryonic factor	DEG_SPOP_SBC_1	141:145	PPSSS	SPOP	0.9989	More...
Q13950	Runt-related transcription factor 2	DEG_SPOP_SBC_1	29:33	PPSSS	SPOP	0.9835	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	810:814	PPSSS	SPOP	0.9752	More...
Q14524	Sodium channel protein type 5 subunit alpha	DEG_SPOP_SBC_1	1962:1966	PPSSS	SPOP	0.9554	More...
Q15637	Splicing factor 1	DEG_SPOP_SBC_1	512:516	PPSSS	SPOP	0.8564	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	2774:2778	PPSSS	SPOP	0.9812	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	1509:1513	PPSSS	SPOP	0.9954	More...
Q5H9R7	Serine/threonine-protein phosphatase 6 regulatory subunit 3	DEG_SPOP_SBC_1	849:853	PPSSS	SPOP	0.9972	More...
Q5HYW2	NHS-like protein 2	DEG_SPOP_SBC_1	737:741	PPSSS	SPOP	0.9584	More...
Q5JU85	IQ motif and SEC7 domain-containing protein 2	DEG_SPOP_SBC_1	275:279	PPSSS	SPOP	0.9552	More...
Q6VY07	Phosphofurin acidic cluster sorting protein 1	DEG_SPOP_SBC_1	782:786	PPSSS	SPOP	0.998	More...
Q70EL1	Inactive ubiquitin carboxyl-terminal hydrolase 54	DEG_SPOP_SBC_1	1605:1609	PPSSS	SPOP	0.8874	More...
Q7L2J0	7SK snRNA methylphosphate capping enzyme	DEG_SPOP_SBC_1	355:359	PPSSS	SPOP	0.9939	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	297:301	PPSSS	SPOP	0.9284	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	393:397	PPSSS	SPOP	0.9958	More...
Q86TB3	Alpha-protein kinase 2	DEG_SPOP_SBC_1	1642:1646	PPSSS	SPOP	0.917	More...
Q86UD0	Suppressor APC domain-containing protein 2	DEG_SPOP_SBC_1	316:320	PPSSS	SPOP	0.991	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	3123:3127	PPSSS	SPOP	0.9592	More...
Q8IXM2	Chromatin complexes subunit BAP18	DEG_SPOP_SBC_1	117:121	PPSSS	SPOP	0.9693	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1551:1555	PPSSS	SPOP	0.6018	More...
Q8N3F8	MICAL-like protein 1	DEG_SPOP_SBC_1	387:391	PPSSS	SPOP	0.9626	More...
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	DEG_SPOP_SBC_1	405:409	PPSSS	SPOP	0.9393	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1931:1935	PPSSS	SPOP	0.8847	More...
Q8TAK6	Oligodendrocyte transcription factor 1	DEG_SPOP_SBC_1	41:45	PPSSS	SPOP	0.9878	More...
Q8TAX7	Mucin-7	DEG_SPOP_SBC_1	179:183	PPSSS	SPOP	0.8542	More...
Q8TAX7	Mucin-7	DEG_SPOP_SBC_1	202:206	PPSSS	SPOP	0.7485	More...
Q8TAX7	Mucin-7	DEG_SPOP_SBC_1	225:229	PPSSS	SPOP	0.9613	More...
Q8WY41	Nanos homolog 1	DEG_SPOP_SBC_1	76:80	PPSSS	SPOP	0.9587	More...
Q8WY91	Peroxynitrite isomerase THAP4	DEG_SPOP_SBC_1	284:288	PPSSS	SPOP	0.9637	More...
Q8WYB5	Histone acetyltransferase KAT6B	DEG_SPOP_SBC_1	1759:1763	PPSSS	SPOP	0.964	More...
Q92630	Dual specificity tyrosine-phosphorylation-regulated kinase 2	DEG_SPOP_SBC_1	568:572	PPSSS	SPOP	0.987	More...
Q92777	Synapsin-2	DEG_SPOP_SBC_1	484:488	PPSSS	SPOP	0.9117	More...
Q96AV8	Transcription factor E2F7	DEG_SPOP_SBC_1	472:476	PPSSS	SPOP	0.9909	More...
Q96EV8	Dysbindin	DEG_SPOP_SBC_1	295:299	PPSSS	SPOP	0.9933	More...
Q96JY6	PDZ and LIM domain protein 2	DEG_SPOP_SBC_1	139:143	PPSSS	SPOP	0.9929	More...
Q96MN9	Zinc finger protein 488	DEG_SPOP_SBC_1	250:254	PPSSS	SPOP	0.8945	More...
Q96SU4	Oxysterol-binding protein-related protein 9	DEG_SPOP_SBC_1	265:269	PPSSS	SPOP	0.9655	More...
Q9BYH1	Seizure 6-like protein	DEG_SPOP_SBC_1	70:74	PPSSS	SPOP	0.9981	More...
Q9BZL6	Serine/threonine-protein kinase D2	DEG_SPOP_SBC_1	234:238	PPSSS	SPOP	0.8427	More...
Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23	DEG_SPOP_SBC_1	1572:1576	PPSSS	SPOP	0.9582	More...
Q9H7S9	Zinc finger protein 703	DEG_SPOP_SBC_1	357:361	PPSSS	SPOP	0.9195	More...
Q9H9P5	Putative E3 ubiquitin-protein ligase UNKL	DEG_SPOP_SBC_1	554:558	PPSSS	SPOP	0.9873	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	165:169	PPSSS	SPOP	0.8162	More...
Q9NQU5	Serine/threonine-protein kinase PAK 6	DEG_SPOP_SBC_1	273:277	PPSSS	SPOP	0.8149	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	1744:1748	PPSSS	SPOP	0.9985	More...
Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	DEG_SPOP_SBC_1	7:11	PPSSS	SPOP	0.8266	More...
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_SPOP_SBC_1	758:762	PPSSS	SPOP	0.9913	More...
Q9Y6X0	SET-binding protein	DEG_SPOP_SBC_1	301:305	PPSSS	SPOP	0.9605	More...
Q5T3F8	CSC1-like protein 2	DEG_SPOP_SBC_1	796:800	PPSSS	SPOP	0.9523	More...
Q7RTM1	Proton channel OTOP1	DEG_SPOP_SBC_1	30:34	PPSSS	SPOP	0.9906	More...
Q8NC96	Adaptin ear-binding coat-associated protein 1	DEG_SPOP_SBC_1	199:203	PPSSS	SPOP	0.9883	More...
Q8TBP0	TBC1 domain family member 16	DEG_SPOP_SBC_1	261:265	PPSSS	SPOP	0.6402	More...
Q96PE2	Rho guanine nucleotide exchange factor 17	DEG_SPOP_SBC_1	858:862	PPSSS	SPOP	0.9891	More...
Q96T92	Insulinoma-associated protein 2	DEG_SPOP_SBC_1	332:336	PPSSS	SPOP	0.9181	More...
Q9HAS0	Protein Njmu-R1	DEG_SPOP_SBC_1	32:36	PPSSS	SPOP	0.9877	More...
Q9Y2L6	FERM domain-containing protein 4B	DEG_SPOP_SBC_1	799:803	PPSSS	SPOP	0.6205	More...
Q8IZD0	Sterile alpha motif domain-containing protein 14	DEG_SPOP_SBC_1	284:288	PPSSS	SPOP	0.9891	More...
E7EW31	Proline-rich basic protein 1	DEG_SPOP_SBC_1	998:1002	PPSSS	SPOP	0.9547	More...
Q8N0V1	Putative uncharacterized protein ZNF295-AS1	DEG_SPOP_SBC_1	20:24	PPSSS	SPOP	0.7709	More...
Q96NR7	Putative uncharacterized protein WWC2-AS2	DEG_SPOP_SBC_1	188:192	PPSSS	SPOP	0.9567	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSSS

Degron related mutations and impact score

Drug responses associated with DTNBP1 mutations

All proteins holding degron of PPSSS