DegronMD - Q8IZD0(SAMD14)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.W240R	TCGA-91-A4BC	LUAD	TCGA	DSGKGS	DEG_SCF_TRCP1_1	243:248	Mutation rewiring degron network	0.25
p.W240R	DO45422	LUAD	ICGC	DSGKGS	DEG_SCF_TRCP1_1	243:248	Mutation rewiring degron network	0.25
p.D294G	TCGA-AP-A051	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.D294G	DO42673	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.L278M	TCGA-B0-4823	KIRC	TCGA	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.L278M	DO18492	KIRC	ICGC	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.L278P	TCGA-B5-A1MX	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.L278P	DO41999	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.P257H	TCGA-CQ-5332	HNSC	TCGA	DSGKGS	DEG_SCF_TRCP1_1	243:248	Mutation rewiring degron network	0.0833
p.P257H	DO14518	HNSC	ICGC	DSGKGS	DEG_SCF_TRCP1_1	243:248	Mutation rewiring degron network	0.0833
p.S239F	TCGA-W3-AA1Q	SKCM	TCGA	DSGKGS	DEG_SCF_TRCP1_1	243:248	Mutation rewiring degron network	0.2222
p.S239F	DO219487	SKCM	ICGC	DSGKGS	DEG_SCF_TRCP1_1	243:248	Mutation rewiring degron network	0.2222
p.L291I	DO222874	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.25
p.G296S	DO23490	LINC	ICGC	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1111
p.G296S	DO51542	PACA	ICGC	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1111
p.S297F	DO222363	MELA	ICGC	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.0833
p.S286R	ACH-000469	Brain Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7427
p.S286R	YH-13	central nervous system	COSMIC	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7427
p.D280E	ACH-000963	Colon/Colorectal Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2222
p.D280E	CCK-81	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.2222
p.L278R	ACH-000991	Colon/Colorectal Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.L278R	SNU-81	large intestine	COSMIC	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1667
p.T242M	ACH-001369	Ovarian Cancer	CCLE	DSGKGS	DEG_SCF_TRCP1_1	243:248	Mutation rewiring degron network	0.3056

Kaplan plot for SAMD14 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SAMD14

UniProt ID: Q8IZD0

Entrez ID: 201191

Protein name: Sterile alpha motif domain-containing protein 14 (SAM domain-containing protein 14)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SAMD14 in