DegronMD

Uniprot ID: Q8IZD0

Source protein: Sterile alpha motif domain-containing protein 14

Source gene: SAMD14

Class: DEG_SCF_TRCP1_1

Location: 243:248

E3 ligase: BTRC

DEGRON score: 0.9698

ASA_SCORE: 80.0333

COIL: 0.957

CONS_SCORE: 0.9535

DSS_SCORE: 0.4731

HELIX: 0.0283

FCONS_SCORE: 1.0259

RIG_SCORE: 0.5944

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.W240R	TCGA-91-A4BC	LUAD	TCGA	DSGKGS	DEG_SCF_TRCP1_1	0.25
p.W240R	DO45422	LUAD	ICGC	DSGKGS	DEG_SCF_TRCP1_1	0.25
p.P257H	TCGA-CQ-5332	HNSC	TCGA	DSGKGS	DEG_SCF_TRCP1_1	0.0833
p.P257H	DO14518	HNSC	ICGC	DSGKGS	DEG_SCF_TRCP1_1	0.0833
p.S239F	TCGA-W3-AA1Q	SKCM	TCGA	DSGKGS	DEG_SCF_TRCP1_1	0.2222
p.S239F	DO219487	SKCM	ICGC	DSGKGS	DEG_SCF_TRCP1_1	0.2222
p.T242M	ACH-001369	Ovarian Cancer	CCLE	DSGKGS	DEG_SCF_TRCP1_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95863	Zinc finger protein SNAI1	DEG_SCF_TRCP1_1	95:100	DSGKGS	BTRC	0.9948	More...
Q8IZD0	Sterile alpha motif domain-containing protein 14	DEG_SCF_TRCP1_1	243:248	DSGKGS	BTRC	0.9698	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons