DegronMD - O14976(GAK)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P898S	TCGA-19-5956	GBM	TCGA	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.0833
p.P898S	DO13863	GBM	ICGC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.0833
p.P1052S	TCGA-2W-A8YY	CESC	TCGA	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation altering degron motif	0.6752
p.P1052S	DO223732	CESC	ICGC	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation altering degron motif	0.6752
p.P781L	TCGA-AG-3727	READ	TCGA	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation altering degron motif	0.7582
p.P781L	DO37138	READ	ICGC	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation altering degron motif	0.7582
p.P898T	TCGA-AO-A128	BRCA	TCGA	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.0833
p.P898T	DO5326	BRCA	ICGC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.0833
p.P874H	TCGA-AP-A051	UCEC	TCGA	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.0556
p.P874H	DO42673	UCEC	ICGC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.0556
p.R790H	TCGA-AX-A2HC	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.1944
p.R790H	DO41572	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.1944
p.D882N	TCGA-D1-A103	UCEC	TCGA	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.2778
p.D882N	DO42312	UCEC	ICGC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.2778
p.D787G	TCGA-D1-A103	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.2778
p.D787G	DO222497	BTCA	ICGC	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.2778
p.D787G	DO42312	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.2778
p.S778C	TCGA-E7-A8O8	BLCA	TCGA	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation blocking phosphorylation signal	0.6944
p.S778C	DO219020	BLCA	ICGC	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation blocking phosphorylation signal	0.6944
p.G1056D	TCGA-EE-A29M	SKCM	TCGA	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation rewiring degron network	0.3056
p.V896L	TCGA-GV-A3QI	BLCA	TCGA	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.1389
p.V896L	DO470	BLCA	ICGC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.1389
p.A788T	DO228126	EOPC	ICGC	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.25
p.P771R	DO223036	ESCA	ICGC	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.0556
p.A1049D	DO223045	ESCA	ICGC	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation altering degron motif	0.6682
p.T1041N	DO228952	LICA	ICGC	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation rewiring degron network	0.1389
p.D879E	DO228978	LICA	ICGC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.1944
p.S784R	DO229026	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation altering degron motif	0.7427
p.P1065T	DO229045	LICA	ICGC	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation rewiring degron network	0.0556
p.H887Q	DO51185	PAEN	ICGC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation altering degron motif	0.7582
p.P782L	DO228176	PBCA	ICGC	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation altering degron motif	0.6471
p.A1045S	DO229232	THCA	ICGC	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation rewiring degron network	0.25
p.G893E	DO229250	THCA	ICGC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.2222
p.P898L	SIDM00791	Chronic Myelogenous Leukemia	GDSC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.0833
p.P898L	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.0833
p.P898L	SIDM01136	Pancreatic Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.0833
p.P898L	SIDM00963	Breast Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.0833
p.P898L	SIDM00217	Colorectal Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.0833
p.P898L	SIDM01098	Neuroblastoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.0833
p.P898L	SIDM01491	Colorectal Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.0833
p.A892V	SIDM00967	Ovarian Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.25
p.A892V	ACH-002181	Ovarian Cancer	CCLE	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.25
p.A892V	OVCA420	ovary	COSMIC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.25
p.A892T	SIDM00281	Other Solid Cancers	GDSC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.25
p.A892T	DJM-1	skin	COSMIC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.25
p.E1042K	SIDM00779	Colorectal Carcinoma	GDSC	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation rewiring degron network	0.1667
p.E1042K	ACH-000491	Colon/Colorectal Cancer	CCLE	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation rewiring degron network	0.1667
p.A1045V	SIDM00621	Ewing's Sarcoma	GDSC	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation rewiring degron network	0.25
p.A1045V	ACH-002113	Bone Cancer	CCLE	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation rewiring degron network	0.25
p.S1060F	SIDM01085	Bladder Carcinoma	GDSC	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation rewiring degron network	0.1944
p.S1060F	ACH-000242	Bladder Cancer	CCLE	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation rewiring degron network	0.1944
p.S1060F	RT4	urinary tract	COSMIC	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation rewiring degron network	0.1944
p.L795R	SIDM00750	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.0556
p.L795R	ACH-000869	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.0556
p.L795R	NCI-H1568	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	781:785	Mutation rewiring degron network	0.0556
p.A1049G	SIDM00980	Gastric Carcinoma	GDSC	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation altering degron motif	0.6429
p.A1049G	ACH-000948	Gastric Cancer	CCLE	VAPTPATE	DEG_SCF_FBW7_2	1048:1055	Mutation altering degron motif	0.6429
p.Q877R	SIDM01451	Pancreatic Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.1389
p.P897L	ACH-000987	Skin Cancer	CCLE	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.1111
p.G885S	ACH-001096	Sarcoma	CCLE	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation altering degron motif	0.5882
p.P881H	AM-38	central nervous system	COSMIC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation rewiring degron network	0.25
p.P887L	NCI-H2405	lung	COSMIC	LGLHSE	LIG_APCC_ABBA_1	884:889	Mutation altering degron motif	0.7582

Kaplan plot for GAK in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GAK

UniProt ID: O14976

Entrez ID: 2580

Protein name: Cyclin-G-associated kinase (EC 2.7.11.1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GAK in