DegronMD

Uniprot ID: O14976

Source protein: Cyclin-G-associated kinase

Source gene: GAK

Class: LIG_APCC_ABBA_1

Location: 884:889

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9793

ASA_SCORE: 76.1833

COIL: 0.779

CONS_SCORE: 0.4624

DSS_SCORE: 0.52

HELIX: 0.1385

FCONS_SCORE: 1.19

RIG_SCORE: 0.7206

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P898S	TCGA-19-5956	GBM	TCGA	LGLHSE	LIG_APCC_ABBA_1	0.0833
p.P898S	DO13863	GBM	ICGC	LGLHSE	LIG_APCC_ABBA_1	0.0833
p.P898T	TCGA-AO-A128	BRCA	TCGA	LGLHSE	LIG_APCC_ABBA_1	0.0833
p.P898T	DO5326	BRCA	ICGC	LGLHSE	LIG_APCC_ABBA_1	0.0833
p.P874H	TCGA-AP-A051	UCEC	TCGA	LGLHSE	LIG_APCC_ABBA_1	0.0556
p.P874H	DO42673	UCEC	ICGC	LGLHSE	LIG_APCC_ABBA_1	0.0556
p.D882N	TCGA-D1-A103	UCEC	TCGA	LGLHSE	LIG_APCC_ABBA_1	0.2778
p.D882N	DO42312	UCEC	ICGC	LGLHSE	LIG_APCC_ABBA_1	0.2778
p.V896L	TCGA-GV-A3QI	BLCA	TCGA	LGLHSE	LIG_APCC_ABBA_1	0.1389
p.V896L	DO470	BLCA	ICGC	LGLHSE	LIG_APCC_ABBA_1	0.1389
p.D879E	DO228978	LICA	ICGC	LGLHSE	LIG_APCC_ABBA_1	0.1944
p.H887Q	DO51185	PAEN	ICGC	LGLHSE	LIG_APCC_ABBA_1	0.7582
p.G893E	DO229250	THCA	ICGC	LGLHSE	LIG_APCC_ABBA_1	0.2222
p.P898L	SIDM00791	Chronic Myelogenous Leukemia	GDSC	LGLHSE	LIG_APCC_ABBA_1	0.0833
p.P898L	SIDM00134	Non-Small Cell Lung Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	0.0833
p.P898L	SIDM01136	Pancreatic Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	0.0833
p.P898L	SIDM00963	Breast Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	0.0833
p.P898L	SIDM00217	Colorectal Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	0.0833
p.P898L	SIDM01098	Neuroblastoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	0.0833
p.P898L	SIDM01491	Colorectal Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	0.0833
p.A892V	SIDM00967	Ovarian Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	0.25
p.A892V	ACH-002181	Ovarian Cancer	CCLE	LGLHSE	LIG_APCC_ABBA_1	0.25
p.A892V	OVCA420	ovary	COSMIC	LGLHSE	LIG_APCC_ABBA_1	0.25
p.A892T	SIDM00281	Other Solid Cancers	GDSC	LGLHSE	LIG_APCC_ABBA_1	0.25
p.A892T	DJM-1	skin	COSMIC	LGLHSE	LIG_APCC_ABBA_1	0.25
p.Q877R	SIDM01451	Pancreatic Carcinoma	GDSC	LGLHSE	LIG_APCC_ABBA_1	0.1389
p.P897L	ACH-000987	Skin Cancer	CCLE	LGLHSE	LIG_APCC_ABBA_1	0.1111
p.G885S	ACH-001096	Sarcoma	CCLE	LGLHSE	LIG_APCC_ABBA_1	0.5882
p.P881H	AM-38	central_nervous_system	COSMIC	LGLHSE	LIG_APCC_ABBA_1	0.25
p.P887L	NCI-H2405	lung	COSMIC	LGLHSE	LIG_APCC_ABBA_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LGLHSE

Degron related mutations and impact score

Drug responses associated with GAK mutations

All proteins holding degron of LGLHSE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14976	Cyclin-G-associated kinase	LIG_APCC_ABBA_1	884:889	LGLHSE	APC,CDC20,FZR1	0.9793	More...