DegronMD

Uniprot ID: O14976

Source protein: Cyclin-G-associated kinase

Source gene: GAK

Class: DEG_SCF_FBW7_2

Location: 1048:1055

E3 ligase: FBXW7

DEGRON score: 0.9849

ASA_SCORE: 80.9375

COIL: 0.929

CONS_SCORE: 0.2654

DSS_SCORE: 0.5691

HELIX: 0.046

FCONS_SCORE: 0.8766

RIG_SCORE: 0.686

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1052S	TCGA-2W-A8YY	CESC	TCGA	VAPTPATE	DEG_SCF_FBW7_2	0.6752
p.P1052S	DO223732	CESC	ICGC	VAPTPATE	DEG_SCF_FBW7_2	0.6752
p.G1056D	TCGA-EE-A29M	SKCM	TCGA	VAPTPATE	DEG_SCF_FBW7_2	0.3056
p.A1049D	DO223045	ESCA	ICGC	VAPTPATE	DEG_SCF_FBW7_2	0.6682
p.T1041N	DO228952	LICA	ICGC	VAPTPATE	DEG_SCF_FBW7_2	0.1389
p.P1065T	DO229045	LICA	ICGC	VAPTPATE	DEG_SCF_FBW7_2	0.0556
p.A1045S	DO229232	THCA	ICGC	VAPTPATE	DEG_SCF_FBW7_2	0.25
p.E1042K	SIDM00779	Colorectal Carcinoma	GDSC	VAPTPATE	DEG_SCF_FBW7_2	0.1667
p.E1042K	ACH-000491	Colon/Colorectal Cancer	CCLE	VAPTPATE	DEG_SCF_FBW7_2	0.1667
p.A1045V	SIDM00621	Ewing's Sarcoma	GDSC	VAPTPATE	DEG_SCF_FBW7_2	0.25
p.A1045V	ACH-002113	Bone Cancer	CCLE	VAPTPATE	DEG_SCF_FBW7_2	0.25
p.S1060F	SIDM01085	Bladder Carcinoma	GDSC	VAPTPATE	DEG_SCF_FBW7_2	0.1944
p.S1060F	ACH-000242	Bladder Cancer	CCLE	VAPTPATE	DEG_SCF_FBW7_2	0.1944
p.S1060F	RT4	urinary_tract	COSMIC	VAPTPATE	DEG_SCF_FBW7_2	0.1944
p.A1049G	SIDM00980	Gastric Carcinoma	GDSC	VAPTPATE	DEG_SCF_FBW7_2	0.6429
p.A1049G	ACH-000948	Gastric Cancer	CCLE	VAPTPATE	DEG_SCF_FBW7_2	0.6429

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O14976	Cyclin-G-associated kinase	DEG_SCF_FBW7_2	1048:1055	VAPTPATE	FBXW7	0.9849	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons