DegronMD - Q92630(DYRK2)

FUNCTION: Serine/threonine-protein kinase involved in the regulation of the mitotic cell cycle, cell proliferation, apoptosis, organization of the cytoskeleton and neurite outgrowth. Functions in part via its role in ubiquitin-dependent proteasomal protein degradation. Functions downstream of ATM and phosphorylates p53/TP53 at 'Ser-46', and thereby contributes to the induction of apoptosis in response to DNA damage. Phosphorylates NFATC1, and thereby inhibits its accumulation in the nucleus and its transcription factor activity. Phosphorylates EIF2B5 at 'Ser-544', enabling its subsequent phosphorylation and inhibition by GSK3B. Likewise, phosphorylation of NFATC1, CRMP2/DPYSL2 and CRMP4/DPYSL3 promotes their subsequent phosphorylation by GSK3B. May play a general role in the priming of GSK3 substrates. Inactivates GYS1 by phosphorylation at 'Ser-641', and potentially also a second phosphorylation site, thus regulating glycogen synthesis. Mediates EDVP E3 ligase complex formation and is required for the phosphorylation and subsequent degradation of KATNA1. Phosphorylates TERT at 'Ser-457', promoting TERT ubiquitination by the EDVP complex. Phosphorylates SIAH2, and thereby increases its ubiquitin ligase activity. Promotes the proteasomal degradation of MYC and JUN, and thereby regulates progress through the mitotic cell cycle and cell proliferation. Promotes proteasomal degradation of GLI2 and GLI3, and thereby plays a role in smoothened and sonic hedgehog signaling. Plays a role in cytoskeleton organization and neurite outgrowth via its phosphorylation of DCX and DPYSL2. Phosphorylates CRMP2/DPYSL2, CRMP4/DPYSL3, DCX, EIF2B5, EIF4EBP1, GLI2, GLI3, GYS1, JUN, MDM2, MYC, NFATC1, p53/TP53, TAU/MAPT and KATNA1. Can phosphorylate histone H1, histone H3 and histone H2B (in vitro). Can phosphorylate CARHSP1 (in vitro). {ECO:0000269|PubMed:11311121, ECO:0000269|PubMed:12588975, ECO:0000269|PubMed:14593110, ECO:0000269|PubMed:15910284, ECO:0000269|PubMed:16511445, ECO:0000269|PubMed:16611631, ECO:0000269|PubMed:17349958, ECO:0000269|PubMed:18455992, ECO:0000269|PubMed:18599021, ECO:0000269|PubMed:19287380, ECO:0000269|PubMed:22307329, ECO:0000269|PubMed:22878263, ECO:0000269|PubMed:23362280, ECO:0000269|PubMed:9748265}. View more >>

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A559S	TCGA-13-2057	OV	TCGA	PPSSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.0833
p.A559S	DO31320	OV	ICGC	PPSSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.0833
p.Q582H	TCGA-16-1460	GBM	TCGA	LRTNLAQMT	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.647
p.Q582H	TCGA-EO-A22R	UCEC	TCGA	LRTNLAQMT	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.647
p.Q582H	DO13360	GBM	ICGC	LRTNLAQMT	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.647
p.Q582H	DO42713	UCEC	ICGC	LRTNLAQMT	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.647
p.A581V	TCGA-AA-3949	COAD	TCGA	LRTNLAQMT	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.5825
p.A581V	TCGA-DU-6397	LGG	TCGA	LRTNLAQMT	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.5825
p.A581V	DO7798	COAD	ICGC	LRTNLAQMT	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.5825
p.A581V	DO22566	LGG	ICGC	LRTNLAQMT	DEG_APCC_DBOX_1	576:584	Mutation altering degron motif	0.5825
p.S572P	TCGA-EE-A2GD	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	568:572	Mutation altering degron motif	0.6752
p.S572P	DO37603	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	568:572	Mutation altering degron motif	0.6752
p.P567H	DO228542	GACA	ICGC	LRTNLAQMT	DEG_APCC_DBOX_1	576:584	Mutation rewiring degron network	0.0833
p.P567H	DO228542	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	568:572	Mutation rewiring degron network	0.3056
p.K575I	SIDM00939	Non-Small Cell Lung Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	568:572	Mutation substituting flanking lysine	0.3611
p.K575I	ACH-000826	Lung Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	568:572	Mutation substituting flanking lysine	0.3611
p.K575I	CAL-12T	lung	COSMIC	PPSSS	DEG_SPOP_SBC_1	568:572	Mutation substituting flanking lysine	0.3611

Kaplan plot for DYRK2 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DYRK2

UniProt ID: Q92630

Entrez ID: 8445

Protein name: Dual specificity tyrosine-phosphorylation-regulated kinase 2 (EC 2.7.12.1)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for DYRK2 in