DegronMD

Uniprot ID: Q92630

Source protein: Dual specificity tyrosine-phosphorylation-regulated kinase 2

Source gene: DYRK2

Class: DEG_APCC_DBOX_1

Location: 576:584

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8902

ASA_SCORE: 106.6556

COIL: 0.8293

CONS_SCORE: 0.3924

DSS_SCORE: 0.5766

HELIX: 0.1371

FCONS_SCORE: 0.8273

RIG_SCORE: 0.7379

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q582H	TCGA-16-1460	GBM	TCGA	LRTNLAQMT	DEG_APCC_DBOX_1	0.647
p.Q582H	TCGA-EO-A22R	UCEC	TCGA	LRTNLAQMT	DEG_APCC_DBOX_1	0.647
p.Q582H	DO13360	GBM	ICGC	LRTNLAQMT	DEG_APCC_DBOX_1	0.647
p.Q582H	DO42713	UCEC	ICGC	LRTNLAQMT	DEG_APCC_DBOX_1	0.647
p.A581V	TCGA-AA-3949	COAD	TCGA	LRTNLAQMT	DEG_APCC_DBOX_1	0.5825
p.A581V	TCGA-DU-6397	LGG	TCGA	LRTNLAQMT	DEG_APCC_DBOX_1	0.5825
p.A581V	DO7798	COAD	ICGC	LRTNLAQMT	DEG_APCC_DBOX_1	0.5825
p.A581V	DO22566	LGG	ICGC	LRTNLAQMT	DEG_APCC_DBOX_1	0.5825
p.P567H	DO228542	GACA	ICGC	LRTNLAQMT	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92630	Dual specificity tyrosine-phosphorylation-regulated kinase 2	DEG_APCC_DBOX_1	576:584	LRTNLAQMT	APC,CDC20,FZR1	0.8902	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons