DegronMD - O95243(MBD4)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Data table is loading....

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L198S	TCGA-AJ-A3EL	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.25
p.L198S	DO41542	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.25
p.T21A	TCGA-AX-A0J0	UCEC	TCGA	TSSERLVPDP	DEG_COP1_1	21:30	Mutation altering degron motif	0.7139
p.T21A	DO41133	UCEC	ICGC	TSSERLVPDP	DEG_COP1_1	21:30	Mutation altering degron motif	0.7139
p.R378C	TCGA-D1-A103	UCEC	TCGA	KEHLHTD	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.2222
p.R378C	DO42312	UCEC	ICGC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.2222
p.R378C	SIDM00578	Neuroblastoma	GDSC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.2222
p.R378C	SIDM00410	Other Blood Cancers	GDSC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.2222
p.R378C	SIDM01018	Hodgkin's Lymphoma	GDSC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.2222
p.R378C	SIDM00497	Colorectal Carcinoma	GDSC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.2222
p.R378C	NB1	autonomic ganglia	COSMIC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.2222
p.V20I	TCGA-EW-A1IZ	BRCA	TCGA	TSSERLVPDP	DEG_COP1_1	21:30	Mutation rewiring degron network	0.3056
p.V20I	DO2937	BRCA	ICGC	TSSERLVPDP	DEG_COP1_1	21:30	Mutation rewiring degron network	0.3056
p.E363Q	DO48437	BLCA	ICGC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.1944
p.E363Q	DO222776	BTCA	ICGC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.1944
p.E381K	DO222776	BTCA	ICGC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.1389
p.G189S	DO9002	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.2778
p.R194W	DO7801	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation altering degron motif	0.8634
p.F201L	DO8264	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.1667
p.G12W	DO234219	ESAD	ICGC	TSSERLVPDP	DEG_COP1_1	21:30	Mutation rewiring degron network	0.0833
p.P191L	DO228542	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation altering degron motif	0.7582
p.P191L	SIDM00479	Esophageal Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation altering degron motif	0.7582
p.L188V	DO23740	LUAD	ICGC	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.25
p.E183Q	DO26469	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation substituting flanking lysine	0.2222
p.R181Q	DO35138	PACA	ICGC	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.0556
p.E381Q	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.1389
p.E381Q	ACH-000875	Lung Cancer	CCLE	KEHLHTD	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.1389
p.E381Q	NCI-H2347	lung	COSMIC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	368:374	Mutation rewiring degron network	0.1389
p.F189L	ACH-000982	Colon/Colorectal Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.2778
p.K200R	EVSA-T	breast	COSMIC	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.1944
p.K200R	SK-HEP-1	liver	COSMIC	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.1944
p.K200E	MFE-319	endometrium	COSMIC	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation rewiring degron network	0.1944
p.R194Q	MFE-296	endometrium	COSMIC	PPSSS	DEG_SPOP_SBC_1	191:195	Mutation altering degron motif	0.7329

Kaplan plot for MBD4 in

Select cancer type:
Download patient class data (Lower:Upper = 50%:50%)

*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MBD4

UniProt ID: O95243

Entrez ID: 8930

Protein name: Methyl-CpG-binding domain protein 4 (EC 3.2.2.-) (Methyl-CpG-binding endonuclease 1) (Methyl-CpG-binding protein MBD4) (Mismatch-specific DNA N-glycosylase)

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for MBD4 in