DegronMD

Uniprot ID: O95243

Source protein: Methyl-CpG-binding domain protein 4

Source gene: MBD4

Class: LIG_APCC_ABBAyCdc20_2

Location: 368:374

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8254

ASA_SCORE: 85.7286

COIL: 0.4703

CONS_SCORE: 0.408

DSS_SCORE: 0.4278

HELIX: 0.275

FCONS_SCORE: 1.0648

RIG_SCORE: 0.8047

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R378C	TCGA-D1-A103	UCEC	TCGA	KEHLHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R378C	DO42312	UCEC	ICGC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R378C	SIDM00578	Neuroblastoma	GDSC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R378C	SIDM00410	Other Blood Cancers	GDSC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R378C	SIDM01018	Hodgkin's Lymphoma	GDSC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R378C	SIDM00497	Colorectal Carcinoma	GDSC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.R378C	NB1	autonomic_ganglia	COSMIC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	0.2222
p.E363Q	DO48437	BLCA	ICGC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E363Q	DO222776	BTCA	ICGC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E381K	DO222776	BTCA	ICGC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E381Q	SIDM00726	Non-Small Cell Lung Carcinoma	GDSC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E381Q	ACH-000875	Lung Cancer	CCLE	KEHLHTD	LIG_APCC_ABBAyCdc20_2	0.1389
p.E381Q	NCI-H2347	lung	COSMIC	KEHLHTD	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95243	Methyl-CpG-binding domain protein 4	LIG_APCC_ABBAyCdc20_2	368:374	KEHLHTD	APC,CDC20,FZR1	0.8254	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons