DegronMD

Uniprot ID: O95243

Source protein: Methyl-CpG-binding domain protein 4

Source gene: MBD4

Class: DEG_COP1_1

Location: 21:30

E3 ligase: COP1

DEGRON score: 0.9856

ASA_SCORE: 87.51

COIL: 0.8708

CONS_SCORE: 0.3158

DSS_SCORE: 0.6887

HELIX: 0.1031

FCONS_SCORE: 1.0908

RIG_SCORE: 0.6724

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T21A	TCGA-AX-A0J0	UCEC	TCGA	TSSERLVPDP	DEG_COP1_1	0.7139
p.T21A	DO41133	UCEC	ICGC	TSSERLVPDP	DEG_COP1_1	0.7139
p.V20I	TCGA-EW-A1IZ	BRCA	TCGA	TSSERLVPDP	DEG_COP1_1	0.3056
p.V20I	DO2937	BRCA	ICGC	TSSERLVPDP	DEG_COP1_1	0.3056
p.G12W	DO234219	ESAD	ICGC	TSSERLVPDP	DEG_COP1_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95243	Methyl-CpG-binding domain protein 4	DEG_COP1_1	21:30	TSSERLVPDP	COP1	0.9856	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons