DegronMD - Q08289(CACNB2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N473K	TCGA-21-1079	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.25
p.P467T	TCGA-21-1083	LUSC	TCGA	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.5919
p.T464N	TCGA-55-8508	LUAD	TCGA	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation blocking phosphorylation signal	0.7222
p.R478H	TCGA-A5-A1OF	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1111
p.R478H	TCGA-D5-6928	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1111
p.R478H	RL95-2	endometrium	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1111
p.L471I	TCGA-AP-A051	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.3056
p.D85N	TCGA-AP-A059	UCEC	TCGA	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2222
p.D85N	SIDM01735	Biliary Tract Carcinoma	GDSC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2222
p.D85N	ACH-000808	Bile Duct Cancer	CCLE	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2222
p.S73L	TCGA-AP-A1DV	UCEC	TCGA	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2778
p.S73L	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2778
p.S73L	ACH-000012	Lung Cancer	CCLE	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2778
p.S73L	ACH-000029	Lung Cancer	CCLE	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2778
p.S73L	HCC-827	lung	COSMIC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2778
p.R70H	TCGA-B5-A0JX	UCEC	TCGA	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1944
p.R70H	DO227996	COCA	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1944
p.R70H	DO222769	COCA	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1944
p.R70H	DO45237	LIRI	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1944
p.R70H	DO43322	UCEC	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1944
p.R70H	SIDM01041	Esophageal Carcinoma	GDSC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1944
p.R70H	SIDM00059	Ovarian Carcinoma	GDSC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1944
p.P466S	TCGA-BR-6565	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.6752
p.D83N	TCGA-CG-4460	STAD	TCGA	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2778
p.P474T	TCGA-CK-6746	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2222
p.E90D	TCGA-CN-6010	HNSC	TCGA	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.0833
p.D91Y	TCGA-CR-7402	HNSC	TCGA	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.0556
p.D91Y	HT-115	large intestine	COSMIC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.0556
p.S67N	TCGA-CV-5430	HNSC	TCGA	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1111
p.S67N	DO14270	HNSC	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1111
p.S84F	TCGA-D3-A1Q6	SKCM	TCGA	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.25
p.S65L	TCGA-KQ-A41P	BLCA	TCGA	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.0556
p.S65L	DO223590	BLCA	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.0556
p.E90Q	TCGA-NC-A5HE	LUSC	TCGA	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.0833
p.V468M	DO51904	BLCA	ICGC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.7208
p.I456M	DO224944	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0556
p.E89K	DO1285	BRCA	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1111
p.E89K	DO43186	UCEC	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1111
p.E89K	DO41488	UCEC	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1111
p.Q461H	DO1297	BRCA	ICGC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1944
p.R70C	DO50348	ESAD	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1944
p.V69A	DO234176	ESAD	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1667
p.V69A	ACH-001270	Sarcoma	CCLE	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1667
p.A73E	DO222469	ESCA	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2778
p.R457C	DO228536	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0833
p.R457C	DO38823	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0833
p.R457C	DO43186	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0833
p.A74S	DO228971	LICA	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.3056
p.D78Y	DO229029	LICA	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation altering degron motif	0.7325
p.P80A	DO45328	LUAD	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation altering degron motif	0.7503
p.R477H	DO26922	LUSC	ICGC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1389
p.R477H	DO46657	PAAD	ICGC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1389
p.A73V	DO45485	LUSC	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2778
p.A73V	DO41235	UCEC	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2778
p.R66W	DO228532	MALY	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.0833
p.E76K	DO229494	SKCA	ICGC	DSYTSRP	CBL_PTK	75:81	Mutation altering degron motif	0.7022
p.K473T	DO37410	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.25
p.R477C	DO47779	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1389
p.Q71K	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2222
p.Q71K	SIDM00796	Head and Neck Carcinoma	GDSC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2222
p.Q71K	ACH-000444	Lung Cancer	CCLE	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2222
p.Q71K	ACH-000740	Head and Neck Cancer	CCLE	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2222
p.Q71K	A253	salivary gland	COSMIC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2222
p.Q71K	LU-99A	lung	COSMIC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.2222
p.R478C	SIDM00890	Melanoma	GDSC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1111
p.R478C	ACH-000580	Skin Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1111
p.R478C	C32	skin	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1111
p.P474H	SIDM00156	Neuroblastoma	GDSC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2222
p.P474H	ACH-002285	Neuroblastoma	CCLE	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2222
p.P474H	NB7	autonomic ganglia	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2222
p.P81Q	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSYTSRP	CBL_PTK	75:81	Mutation altering degron motif	0.7035
p.P81Q	ACH-002253	Lymphoma	CCLE	DSYTSRP	CBL_PTK	75:81	Mutation altering degron motif	0.7035
p.P81Q	JSC-1	haematopoietic and lymphoid tissue	COSMIC	DSYTSRP	CBL_PTK	75:81	Mutation altering degron motif	0.7035
p.S84Y	SIDM01588	Endometrial Carcinoma	GDSC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.25
p.S84Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.25
p.S465Y	H513	pleura	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.3056
p.Q478R	KATOIII	stomach	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1111
p.A480S	RERF-GC-1B	stomach	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0556
p.E468Q	TE-15	oesophagus	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.6744
p.E471Q	TE-15	oesophagus	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.3056
p.E472K	ACN	autonomic ganglia	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2778
p.E465K	ACN	autonomic ganglia	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.3056
p.S469Y	H513	pleura	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.712
p.E479K	ACN	autonomic ganglia	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.0833
p.A473S	RERF-GC-1B	stomach	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.25
p.A70S	RERF-GC-1B	stomach	COSMIC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.1944
p.R458H	RL95-2	endometrium	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1111
p.Q474R	KATOIII	stomach	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.2222
p.R90H	SNU-1040	large intestine	COSMIC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.0833
p.E80V	Sarc9371	bone	COSMIC	DSYTSRP	CBL_PTK	75:81	Mutation altering degron motif	0.7693
p.E469Q	TE-15	oesophagus	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation altering degron motif	0.6744
p.R90C	SN12C	kidney	COSMIC	DSYTSRP	CBL_PTK	75:81	Mutation rewiring degron network	0.0833
p.E475Q	TE-15	oesophagus	COSMIC	PPSSS	DEG_SPOP_SBC_1	466:470	Mutation rewiring degron network	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CACNB2

UniProt ID: Q08289

Entrez ID: 783

Protein name: Voltage-dependent L-type calcium channel subunit beta-2 (CAB2) (Calcium channel voltage-dependent subunit beta 2) (Lambert-Eaton myasthenic syndrome antigen B) (MYSB)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CACNB2 in