DegronMD

Uniprot ID: Q08289

Source protein: Voltage-dependent L-type calcium channel subunit beta-2

Source gene: CACNB2

Class: CBL_PTK

Location: 75:81

E3 ligase: CBL

DEGRON score: 0.9882

ASA_SCORE: 66.3286

COIL: 0.7486

CONS_SCORE: 0.5687

DSS_SCORE: 0.6441

HELIX: 0.0694

FCONS_SCORE: 1.1639

RIG_SCORE: 0.6031

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D85N	TCGA-AP-A059	UCEC	TCGA	DSYTSRP	CBL_PTK	0.2222
p.D85N	SIDM01735	Biliary Tract Carcinoma	GDSC	DSYTSRP	CBL_PTK	0.2222
p.D85N	ACH-000808	Bile Duct Cancer	CCLE	DSYTSRP	CBL_PTK	0.2222
p.S73L	TCGA-AP-A1DV	UCEC	TCGA	DSYTSRP	CBL_PTK	0.2778
p.S73L	SIDM01067	Non-Small Cell Lung Carcinoma	GDSC	DSYTSRP	CBL_PTK	0.2778
p.S73L	ACH-000012	Lung Cancer	CCLE	DSYTSRP	CBL_PTK	0.2778
p.S73L	ACH-000029	Lung Cancer	CCLE	DSYTSRP	CBL_PTK	0.2778
p.S73L	HCC-827	lung	COSMIC	DSYTSRP	CBL_PTK	0.2778
p.R70H	TCGA-B5-A0JX	UCEC	TCGA	DSYTSRP	CBL_PTK	0.1944
p.R70H	DO227996	COCA	ICGC	DSYTSRP	CBL_PTK	0.1944
p.R70H	DO222769	COCA	ICGC	DSYTSRP	CBL_PTK	0.1944
p.R70H	DO45237	LIRI	ICGC	DSYTSRP	CBL_PTK	0.1944
p.R70H	DO43322	UCEC	ICGC	DSYTSRP	CBL_PTK	0.1944
p.R70H	SIDM01041	Esophageal Carcinoma	GDSC	DSYTSRP	CBL_PTK	0.1944
p.R70H	SIDM00059	Ovarian Carcinoma	GDSC	DSYTSRP	CBL_PTK	0.1944
p.D83N	TCGA-CG-4460	STAD	TCGA	DSYTSRP	CBL_PTK	0.2778
p.E90D	TCGA-CN-6010	HNSC	TCGA	DSYTSRP	CBL_PTK	0.0833
p.D91Y	TCGA-CR-7402	HNSC	TCGA	DSYTSRP	CBL_PTK	0.0556
p.D91Y	HT-115	large_intestine	COSMIC	DSYTSRP	CBL_PTK	0.0556
p.S67N	TCGA-CV-5430	HNSC	TCGA	DSYTSRP	CBL_PTK	0.1111
p.S67N	DO14270	HNSC	ICGC	DSYTSRP	CBL_PTK	0.1111
p.S84F	TCGA-D3-A1Q6	SKCM	TCGA	DSYTSRP	CBL_PTK	0.25
p.S65L	TCGA-KQ-A41P	BLCA	TCGA	DSYTSRP	CBL_PTK	0.0556
p.S65L	DO223590	BLCA	ICGC	DSYTSRP	CBL_PTK	0.0556
p.E90Q	TCGA-NC-A5HE	LUSC	TCGA	DSYTSRP	CBL_PTK	0.0833
p.E89K	DO1285	BRCA	ICGC	DSYTSRP	CBL_PTK	0.1111
p.E89K	DO43186	UCEC	ICGC	DSYTSRP	CBL_PTK	0.1111
p.E89K	DO41488	UCEC	ICGC	DSYTSRP	CBL_PTK	0.1111
p.R70C	DO50348	ESAD	ICGC	DSYTSRP	CBL_PTK	0.1944
p.V69A	DO234176	ESAD	ICGC	DSYTSRP	CBL_PTK	0.1667
p.V69A	ACH-001270	Sarcoma	CCLE	DSYTSRP	CBL_PTK	0.1667
p.A73E	DO222469	ESCA	ICGC	DSYTSRP	CBL_PTK	0.2778
p.A74S	DO228971	LICA	ICGC	DSYTSRP	CBL_PTK	0.3056
p.D78Y	DO229029	LICA	ICGC	DSYTSRP	CBL_PTK	0.7325
p.P80A	DO45328	LUAD	ICGC	DSYTSRP	CBL_PTK	0.7503
p.A73V	DO45485	LUSC	ICGC	DSYTSRP	CBL_PTK	0.2778
p.A73V	DO41235	UCEC	ICGC	DSYTSRP	CBL_PTK	0.2778
p.R66W	DO228532	MALY	ICGC	DSYTSRP	CBL_PTK	0.0833
p.E76K	DO229494	SKCA	ICGC	DSYTSRP	CBL_PTK	0.7022
p.Q71K	SIDM01219	Non-Small Cell Lung Carcinoma	GDSC	DSYTSRP	CBL_PTK	0.2222
p.Q71K	SIDM00796	Head and Neck Carcinoma	GDSC	DSYTSRP	CBL_PTK	0.2222
p.Q71K	ACH-000444	Lung Cancer	CCLE	DSYTSRP	CBL_PTK	0.2222
p.Q71K	ACH-000740	Head and Neck Cancer	CCLE	DSYTSRP	CBL_PTK	0.2222
p.Q71K	A253	salivary_gland	COSMIC	DSYTSRP	CBL_PTK	0.2222
p.Q71K	LU-99A	lung	COSMIC	DSYTSRP	CBL_PTK	0.2222
p.P81Q	SIDM00688	B-Cell Non-Hodgkin's Lymphoma	GDSC	DSYTSRP	CBL_PTK	0.7035
p.P81Q	ACH-002253	Lymphoma	CCLE	DSYTSRP	CBL_PTK	0.7035
p.P81Q	JSC-1	haematopoietic_and_lymphoid_tissue	COSMIC	DSYTSRP	CBL_PTK	0.7035
p.S84Y	SIDM01588	Endometrial Carcinoma	GDSC	DSYTSRP	CBL_PTK	0.25
p.S84Y	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSYTSRP	CBL_PTK	0.25
p.A70S	RERF-GC-1B	stomach	COSMIC	DSYTSRP	CBL_PTK	0.1944
p.R90H	SNU-1040	large_intestine	COSMIC	DSYTSRP	CBL_PTK	0.0833
p.E80V	Sarc9371	bone	COSMIC	DSYTSRP	CBL_PTK	0.7693
p.R90C	SN12C	kidney	COSMIC	DSYTSRP	CBL_PTK	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00305	Voltage-dependent L-type calcium channel subunit beta-4	CBL_PTK	53:59	DSYTSRP	CBL	0.9936	More...
P54284	Voltage-dependent L-type calcium channel subunit beta-3	CBL_PTK	19:25	DSYTSRP	CBL	0.9665	More...
Q08289	Voltage-dependent L-type calcium channel subunit beta-2	CBL_PTK	75:81	DSYTSRP	CBL	0.9882	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: DSYTSRP

Degron related mutations and impact score

Drug responses associated with CACNB2 mutations

All proteins holding degron of DSYTSRP