DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
CPH
CGC
Degron:
DSYTSRP
Uniprot ID:
P54284
Source protein:
Voltage-dependent L-type calcium channel subunit beta-3
Source gene:
CACNB3
Class:
CBL_PTK
Location:
19:25
E3 ligase:
CBL
DEGRON score:
0.9665
ASA_SCORE:
77.7571
COIL:
0.8951
CONS_SCORE:
0.3471
DSS_SCORE:
0.6373
HELIX:
0.0464
FCONS_SCORE:
1.0095
RIG_SCORE:
0.6348
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.G16C
TCGA-60-2723
LUSC
TCGA
DSYTSRP
CBL_PTK
0.25
p.G16C
DO27152
LUSC
ICGC
DSYTSRP
CBL_PTK
0.25
p.G16C
DO46333
OV
ICGC
DSYTSRP
CBL_PTK
0.25
p.V31F
DO229019
LICA
ICGC
DSYTSRP
CBL_PTK
0.1667
p.G9V
DO229024
LICA
ICGC
DSYTSRP
CBL_PTK
0.0556
p.R24H
SIDM00856
Other Solid Cancers
GDSC
DSYTSRP
CBL_PTK
0.7133
p.D12G
ACH-000978
Endometrial/Uterine Cancer
CCLE
DSYTSRP
CBL_PTK
0.1389
p.D12G
EN
endometrium
COSMIC
DSYTSRP
CBL_PTK
0.1389
Drug responses associated with CACNB3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of DSYTSRP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00305
Voltage-dependent L-type calcium channel subunit beta-4
CBL_PTK
53:59
DSYTSRP
CBL
0.9936
More...
P54284
Voltage-dependent L-type calcium channel subunit beta-3
CBL_PTK
19:25
DSYTSRP
CBL
0.9665
More...
Q08289
Voltage-dependent L-type calcium channel subunit beta-2
CBL_PTK
75:81
DSYTSRP
CBL
0.9882
More...
