DegronMD

Uniprot ID: O00305

Source protein: Voltage-dependent L-type calcium channel subunit beta-4

Source gene: CACNB4

Class: CBL_PTK

Location: 53:59

E3 ligase: CBL

DEGRON score: 0.9936

ASA_SCORE: 73.3

COIL: 0.7251

CONS_SCORE: 0.4959

DSS_SCORE: 0.6195

HELIX: 0.0459

FCONS_SCORE: 1.1957

RIG_SCORE: 0.6061

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D69N	TCGA-D3-A3MR	SKCM	TCGA	DSYTSRP	CBL_PTK	0.0556
p.P59S	TCGA-DA-A1HV	SKCM	TCGA	DSYTSRP	CBL_PTK	0.6752
p.S57R	TCGA-DX-A6YS	SARC	TCGA	DSYTSRP	CBL_PTK	0.6316
p.A54E	DO229029	LICA	ICGC	DSYTSRP	CBL_PTK	0.7701
p.D51N	DO47256	SKCM	ICGC	DSYTSRP	CBL_PTK	0.2778
p.R52W	DO38567	STAD	ICGC	DSYTSRP	CBL_PTK	0.3056
p.A64S	DO41999	UCEC	ICGC	DSYTSRP	CBL_PTK	0.1944
p.V64A	SIDM01059	Melanoma	GDSC	DSYTSRP	CBL_PTK	0.1944
p.V64A	IPC-298	skin	COSMIC	DSYTSRP	CBL_PTK	0.1944
p.D63N	SIDM01664	Prostate Carcinoma	GDSC	DSYTSRP	CBL_PTK	0.2222
p.A59T	ACH-000993	Endometrial/Uterine Cancer	CCLE	DSYTSRP	CBL_PTK	0.7139
p.D61E	ACH-001127	Leukemia	CCLE	DSYTSRP	CBL_PTK	0.2778
p.D61E	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	DSYTSRP	CBL_PTK	0.2778
p.V46A	IPC-298	skin	COSMIC	DSYTSRP	CBL_PTK	0.1389
p.D60Y	Mewo	skin	COSMIC	DSYTSRP	CBL_PTK	0.3056
p.Y57C	JHH-7	liver	COSMIC	DSYTSRP	CBL_PTK	0.7087

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00305	Voltage-dependent L-type calcium channel subunit beta-4	CBL_PTK	53:59	DSYTSRP	CBL	0.9936	More...
P54284	Voltage-dependent L-type calcium channel subunit beta-3	CBL_PTK	19:25	DSYTSRP	CBL	0.9665	More...
Q08289	Voltage-dependent L-type calcium channel subunit beta-2	CBL_PTK	75:81	DSYTSRP	CBL	0.9882	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons