DegronMD - O95714(HERC2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G3369V	TCGA-05-4249	LUAD	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.1389
p.G3369V	DO23891	LUAD	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.1389
p.G3369C	TCGA-05-4249	LUAD	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.1389
p.G3369C	DO23891	LUAD	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.1389
p.A3971T	TCGA-14-0736	GBM	TCGA	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation rewiring degron network	0.2778
p.A3971T	DO10875	GBM	ICGC	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation rewiring degron network	0.2778
p.A3971T	ACH-001719	Ovarian Cancer	CCLE	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation rewiring degron network	0.2778
p.G1798V	TCGA-75-6214	LUAD	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.1389
p.G1798V	DO24830	LUAD	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.1389
p.R2646G	TCGA-A5-A0R7	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.0556
p.R2646G	DO42225	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.0556
p.S3373Y	TCGA-AN-A046	BRCA	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.25
p.S3373Y	DO1285	BRCA	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.25
p.L3380F	TCGA-AX-A05Z	UCEC	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation altering degron motif	0.6981
p.L3380F	DO40884	UCEC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation altering degron motif	0.6981
p.G1774E	TCGA-AX-A05Z	UCEC	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.0833
p.G1774E	DO40884	UCEC	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.0833
p.L3387V	TCGA-AX-A06F	UCEC	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.25
p.L3387V	DO41752	UCEC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.25
p.G1798S	TCGA-AX-A0J1	UCEC	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.1389
p.G1798S	DO228946	LICA	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.1389
p.G1798S	DO41199	UCEC	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.1389
p.L3384I	TCGA-AX-A2HC	UCEC	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation altering degron motif	0.6063
p.L3384I	DO222798	COCA	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation altering degron motif	0.6063
p.L3384I	DO41572	UCEC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation altering degron motif	0.6063
p.S3368N	TCGA-BG-A222	UCEC	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.1111
p.S3368N	DO42977	UCEC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.1111
p.Y2622N	TCGA-CG-5726	STAD	TCGA	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.0556
p.Y2622N	DO38483	STAD	ICGC	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.0556
p.R1784L	TCGA-CJ-5680	KIRC	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation altering degron motif	0.8428
p.R1784L	DO225025	BRCA	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation altering degron motif	0.8428
p.R1784L	DO17607	KIRC	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation altering degron motif	0.8428
p.R1784L	DO229234	THCA	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation altering degron motif	0.8428
p.D3388V	TCGA-D1-A15X	UCEC	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.2222
p.D3388V	DO43274	UCEC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.2222
p.R1784H	TCGA-D1-A16F	UCEC	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation altering degron motif	0.8244
p.R1784H	DO42408	UCEC	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation altering degron motif	0.8244
p.P1781Q	TCGA-DZ-6133	KIRP	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.2778
p.P1781Q	DO20762	KIRP	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.2778
p.R1784S	TCGA-EE-A29X	SKCM	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation altering degron motif	0.7427
p.R1784S	DO37595	SKCM	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation altering degron motif	0.7427
p.S2636F	TCGA-EE-A2A1	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation altering degron motif	0.7982
p.S2636F	DO38045	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation altering degron motif	0.7982
p.G3967R	TCGA-EE-A2M7	SKCM	TCGA	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation altering degron motif	0.6457
p.G3967R	DO37847	SKCM	ICGC	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation altering degron motif	0.6457
p.K3366T	TCGA-EO-A3AV	UCEC	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation blocking ubiquitination signal	0.5
p.K3366T	DO52412	UCEC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation blocking ubiquitination signal	0.5
p.E3969A	TCGA-FI-A2D5	UCEC	TCGA	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation altering degron motif	0.659
p.E3969A	DO41331	UCEC	ICGC	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation altering degron motif	0.659
p.A1783S	TCGA-FI-A2D5	UCEC	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation altering degron motif	0.6477
p.A1783S	DO41331	UCEC	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation altering degron motif	0.6477
p.P1775Q	TCGA-FS-A1ZM	SKCM	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.1111
p.P1775Q	DO37731	SKCM	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.1111
p.G1778W	TCGA-G2-A2EJ	BLCA	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.1944
p.G1778W	DO554	BLCA	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.1944
p.Y2630H	TCGA-PK-A5HB	ACC	TCGA	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.2778
p.L3385S	TCGA-XK-AAIW	PRAD	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.3056
p.L3385S	DO51407	PRAD	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.3056
p.A1799T	DO222427	BTCA	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.1111
p.K3366E	DO234371	ESAD	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation blocking ubiquitination signal	0.5
p.R3377H	DO223142	ESCA	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation altering degron motif	0.8244
p.H2624R	DO233823	GACA	ICGC	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.1111
p.H2624R	DO50834	LIRI	ICGC	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.1111
p.S1776N	DO50970	LICA	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.1389
p.Q3394H	DO231691	LINC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.0556
p.S3368R	DO228889	MALY	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.1111
p.R2646Q	DO51510	PACA	ICGC	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.0556
p.R2646L	DO229275	THCA	ICGC	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.0556
p.T1779A	SIDM02059	Colorectal Carcinoma	GDSC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.2222
p.M1792V	SIDM00135	Breast Carcinoma	GDSC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.3056
p.M1792V	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.3056
p.P1781L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.2778
p.P1781L	ACH-000995	Leukemia	CCLE	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.2778
p.P1781L	Jurkat	haematopoietic and lymphoid tissue	COSMIC	ARFLLVMLS	DEG_APCC_DBOX_1	1783:1791	Mutation rewiring degron network	0.2778
p.G3970V	SIDM00373	Endometrial Carcinoma	GDSC	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation rewiring degron network	0.3056
p.G3970V	ACH-000974	Endometrial/Uterine Cancer	CCLE	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation rewiring degron network	0.3056
p.G3970V	ACH-002026	Endometrial/Uterine Cancer	CCLE	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation rewiring degron network	0.3056
p.G3970V	SNG-M	endometrium	COSMIC	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation rewiring degron network	0.3056
p.P3978L	SIDM00007	Other Solid Cancers	GDSC	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation rewiring degron network	0.0833
p.P3978L	ACH-001550	Skin Cancer	CCLE	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation rewiring degron network	0.0833
p.P3978L	MCC13	skin	COSMIC	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation rewiring degron network	0.0833
p.P3978S	SIDM00007	Other Solid Cancers	GDSC	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation rewiring degron network	0.0833
p.P3978S	ACH-001550	Skin Cancer	CCLE	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation rewiring degron network	0.0833
p.P3978S	MCC13	skin	COSMIC	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation rewiring degron network	0.0833
p.L3391Q	SIDM00898	Breast Carcinoma	GDSC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.1389
p.L3391Q	ACH-000017	Breast Cancer	CCLE	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.1389
p.L3391Q	ACH-000248	Breast Cancer	CCLE	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.1389
p.L3391Q	AU565	breast	COSMIC	NRPSLAKIL	DEG_APCC_DBOX_1	3376:3384	Mutation rewiring degron network	0.1389
p.R2646W	SIDM00324	Neuroblastoma	GDSC	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.0556
p.R2646W	ACH-001674	Neuroblastoma	CCLE	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.0556
p.R2646W	TGW	autonomic ganglia	COSMIC	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.0556
p.V2645M	SIDM00976	Melanoma	GDSC	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.0833
p.V2645M	ACH-002205	Skin Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.0833
p.V2645M	WM1552C	skin	COSMIC	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation rewiring degron network	0.0833
p.E3969K	SIDM01735	Biliary Tract Carcinoma	GDSC	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation altering degron motif	0.591
p.E3969K	ACH-000808	Bile Duct Cancer	CCLE	HRGQLGGIE	DEG_APCC_DBOX_1	3961:3969	Mutation altering degron motif	0.591
p.S2635Y	SIDM01611	Endometrial Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation altering degron motif	0.712
p.S2635Y	ACH-000996	Endometrial/Uterine Cancer	CCLE	PPSSS	DEG_SPOP_SBC_1	2632:2636	Mutation altering degron motif	0.712

DegronMD: protein-targeted degradation, mutation and drug response to degrons

HERC2

UniProt ID: O95714

Entrez ID: 8924

Protein name: E3 ubiquitin-protein ligase HERC2 (EC 2.3.2.26) (HECT domain and RCC1-like domain-containing protein 2) (HECT-type E3 ubiquitin transferase HERC2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for HERC2 in