DegronMD

Uniprot ID: O95714

Source protein: E3 ubiquitin-protein ligase HERC2

Source gene: HERC2

Class: DEG_APCC_DBOX_1

Location: 1783:1791

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5269

ASA_SCORE: 20.6

COIL: 0.0111

CONS_SCORE: 0.5125

DSS_SCORE: 0.0583

HELIX: 0.9876

FCONS_SCORE: 1.2654

RIG_SCORE: 0.9185

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G1798V	TCGA-75-6214	LUAD	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	0.1389
p.G1798V	DO24830	LUAD	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.1389
p.G1774E	TCGA-AX-A05Z	UCEC	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	0.0833
p.G1774E	DO40884	UCEC	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.0833
p.G1798S	TCGA-AX-A0J1	UCEC	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	0.1389
p.G1798S	DO228946	LICA	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.1389
p.G1798S	DO41199	UCEC	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.1389
p.R1784L	TCGA-CJ-5680	KIRC	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	0.8428
p.R1784L	DO225025	BRCA	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.8428
p.R1784L	DO17607	KIRC	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.8428
p.R1784L	DO229234	THCA	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.8428
p.R1784H	TCGA-D1-A16F	UCEC	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	0.8244
p.R1784H	DO42408	UCEC	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.8244
p.P1781Q	TCGA-DZ-6133	KIRP	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	0.2778
p.P1781Q	DO20762	KIRP	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.2778
p.R1784S	TCGA-EE-A29X	SKCM	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	0.7427
p.R1784S	DO37595	SKCM	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.7427
p.A1783S	TCGA-FI-A2D5	UCEC	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	0.6477
p.A1783S	DO41331	UCEC	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.6477
p.P1775Q	TCGA-FS-A1ZM	SKCM	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	0.1111
p.P1775Q	DO37731	SKCM	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.1111
p.G1778W	TCGA-G2-A2EJ	BLCA	TCGA	ARFLLVMLS	DEG_APCC_DBOX_1	0.1944
p.G1778W	DO554	BLCA	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.1944
p.A1799T	DO222427	BTCA	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.1111
p.S1776N	DO50970	LICA	ICGC	ARFLLVMLS	DEG_APCC_DBOX_1	0.1389
p.T1779A	SIDM02059	Colorectal Carcinoma	GDSC	ARFLLVMLS	DEG_APCC_DBOX_1	0.2222
p.M1792V	SIDM00135	Breast Carcinoma	GDSC	ARFLLVMLS	DEG_APCC_DBOX_1	0.3056
p.M1792V	SIDM00320	Non-Small Cell Lung Carcinoma	GDSC	ARFLLVMLS	DEG_APCC_DBOX_1	0.3056
p.P1781L	SIDM01016	T-Lymphoblastic Leukemia	GDSC	ARFLLVMLS	DEG_APCC_DBOX_1	0.2778
p.P1781L	ACH-000995	Leukemia	CCLE	ARFLLVMLS	DEG_APCC_DBOX_1	0.2778
p.P1781L	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	ARFLLVMLS	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: ARFLLVMLS

Degron related mutations and impact score

Drug responses associated with HERC2 mutations

All proteins holding degron of ARFLLVMLS

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95714	E3 ubiquitin-protein ligase HERC2	DEG_APCC_DBOX_1	1783:1791	ARFLLVMLS	APC,CDC20,FZR1	0.5269	More...