DegronMD

Uniprot ID: O95714

Source protein: E3 ubiquitin-protein ligase HERC2

Source gene: HERC2

Class: DEG_APCC_DBOX_1

Location: 3376:3384

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9812

ASA_SCORE: 53.4667

COIL: 0.3637

CONS_SCORE: 0.5012

DSS_SCORE: 0.3239

HELIX: 0.5356

FCONS_SCORE: 1.3317

RIG_SCORE: 0.7474

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G3369V	TCGA-05-4249	LUAD	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	0.1389
p.G3369V	DO23891	LUAD	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.1389
p.G3369C	TCGA-05-4249	LUAD	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	0.1389
p.G3369C	DO23891	LUAD	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.1389
p.S3373Y	TCGA-AN-A046	BRCA	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	0.25
p.S3373Y	DO1285	BRCA	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.25
p.L3380F	TCGA-AX-A05Z	UCEC	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	0.6981
p.L3380F	DO40884	UCEC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.6981
p.L3387V	TCGA-AX-A06F	UCEC	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	0.25
p.L3387V	DO41752	UCEC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.25
p.L3384I	TCGA-AX-A2HC	UCEC	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	0.6063
p.L3384I	DO222798	COCA	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.6063
p.L3384I	DO41572	UCEC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.6063
p.S3368N	TCGA-BG-A222	UCEC	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	0.1111
p.S3368N	DO42977	UCEC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.1111
p.D3388V	TCGA-D1-A15X	UCEC	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	0.2222
p.D3388V	DO43274	UCEC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.2222
p.K3366T	TCGA-EO-A3AV	UCEC	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	0.5
p.K3366T	DO52412	UCEC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.5
p.L3385S	TCGA-XK-AAIW	PRAD	TCGA	NRPSLAKIL	DEG_APCC_DBOX_1	0.3056
p.L3385S	DO51407	PRAD	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.3056
p.K3366E	DO234371	ESAD	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.5
p.R3377H	DO223142	ESCA	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.8244
p.Q3394H	DO231691	LINC	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.0556
p.S3368R	DO228889	MALY	ICGC	NRPSLAKIL	DEG_APCC_DBOX_1	0.1111
p.L3391Q	SIDM00898	Breast Carcinoma	GDSC	NRPSLAKIL	DEG_APCC_DBOX_1	0.1389
p.L3391Q	ACH-000017	Breast Cancer	CCLE	NRPSLAKIL	DEG_APCC_DBOX_1	0.1389
p.L3391Q	ACH-000248	Breast Cancer	CCLE	NRPSLAKIL	DEG_APCC_DBOX_1	0.1389
p.L3391Q	AU565	breast	COSMIC	NRPSLAKIL	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NRPSLAKIL

Degron related mutations and impact score

Drug responses associated with HERC2 mutations

All proteins holding degron of NRPSLAKIL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95714	E3 ubiquitin-protein ligase HERC2	DEG_APCC_DBOX_1	3376:3384	NRPSLAKIL	APC,CDC20,FZR1	0.9812	More...