DegronMD

Uniprot ID: O95714

Source protein: E3 ubiquitin-protein ligase HERC2

Source gene: HERC2

Class: DEG_APCC_DBOX_1

Location: 3961:3969

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8828

ASA_SCORE: 60.7222

COIL: 0.7391

CONS_SCORE: 0.6462

DSS_SCORE: 0.3507

HELIX: 0.052

FCONS_SCORE: 1.2694

RIG_SCORE: 0.6919

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A3971T	TCGA-14-0736	GBM	TCGA	HRGQLGGIE	DEG_APCC_DBOX_1	0.2778
p.A3971T	DO10875	GBM	ICGC	HRGQLGGIE	DEG_APCC_DBOX_1	0.2778
p.A3971T	ACH-001719	Ovarian Cancer	CCLE	HRGQLGGIE	DEG_APCC_DBOX_1	0.2778
p.G3967R	TCGA-EE-A2M7	SKCM	TCGA	HRGQLGGIE	DEG_APCC_DBOX_1	0.6457
p.G3967R	DO37847	SKCM	ICGC	HRGQLGGIE	DEG_APCC_DBOX_1	0.6457
p.E3969A	TCGA-FI-A2D5	UCEC	TCGA	HRGQLGGIE	DEG_APCC_DBOX_1	0.659
p.E3969A	DO41331	UCEC	ICGC	HRGQLGGIE	DEG_APCC_DBOX_1	0.659
p.G3970V	SIDM00373	Endometrial Carcinoma	GDSC	HRGQLGGIE	DEG_APCC_DBOX_1	0.3056
p.G3970V	ACH-000974	Endometrial/Uterine Cancer	CCLE	HRGQLGGIE	DEG_APCC_DBOX_1	0.3056
p.G3970V	ACH-002026	Endometrial/Uterine Cancer	CCLE	HRGQLGGIE	DEG_APCC_DBOX_1	0.3056
p.G3970V	SNG-M	endometrium	COSMIC	HRGQLGGIE	DEG_APCC_DBOX_1	0.3056
p.P3978L	SIDM00007	Other Solid Cancers	GDSC	HRGQLGGIE	DEG_APCC_DBOX_1	0.0833
p.P3978L	ACH-001550	Skin Cancer	CCLE	HRGQLGGIE	DEG_APCC_DBOX_1	0.0833
p.P3978L	MCC13	skin	COSMIC	HRGQLGGIE	DEG_APCC_DBOX_1	0.0833
p.P3978S	SIDM00007	Other Solid Cancers	GDSC	HRGQLGGIE	DEG_APCC_DBOX_1	0.0833
p.P3978S	ACH-001550	Skin Cancer	CCLE	HRGQLGGIE	DEG_APCC_DBOX_1	0.0833
p.P3978S	MCC13	skin	COSMIC	HRGQLGGIE	DEG_APCC_DBOX_1	0.0833
p.E3969K	SIDM01735	Biliary Tract Carcinoma	GDSC	HRGQLGGIE	DEG_APCC_DBOX_1	0.591
p.E3969K	ACH-000808	Bile Duct Cancer	CCLE	HRGQLGGIE	DEG_APCC_DBOX_1	0.591

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O95714	E3 ubiquitin-protein ligase HERC2	DEG_APCC_DBOX_1	3961:3969	HRGQLGGIE	APC,CDC20,FZR1	0.8828	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons