DegronMD

Uniprot ID: P53779

Source protein: Mitogen-activated protein kinase 10

Source gene: MAPK10

Class: DEG_SPOP_SBC_1

Location: 428:432

E3 ligase: SPOP

DEGRON score: 0.9915

ASA_SCORE: 79.46

COIL: 0.9458

CONS_SCORE: 0.3004

DSS_SCORE: 0.6242

HELIX: 0.038

FCONS_SCORE: 0.9651

RIG_SCORE: 0.5761

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E425G	TCGA-AD-6889	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	0.25
p.E425K	TCGA-G2-AA3C	BLCA	TCGA	PPSSS	DEG_SPOP_SBC_1	0.25
p.S437F	SIDM01031	Esophageal Squamous Cell Carcinoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.1944
p.S437F	KYSE-150	oesophagus	COSMIC	PPSSS	DEG_SPOP_SBC_1	0.1944
p.Q422R	DO30660	OV	ICGC	PPSSS	DEG_SPOP_SBC_1	0.1667
p.S438T	SIDM01561	Melanoma	GDSC	PPSSS	DEG_SPOP_SBC_1	0.1667
p.S440F	KYSE-150	oesophagus	COSMIC	PPSSS	DEG_SPOP_SBC_1	0.1111
p.A419T	TCGA-B5-A5OD	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	0.0833
p.D442N	TCGA-BF-AAP4	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	0.0556
p.D442N	TCGA-EY-A549	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	0.0556
p.G418C	TCGA-FZ-5920	PAAD	TCGA	PPSSS	DEG_SPOP_SBC_1	0.0556

Showing 1 to 11 of 11 entries

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Drug responses associated with MAPK10 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM01086	ALL\|leukemia	p.E323K (No)	GDSC	JNK-9L	0.3603
SIDM00963	BRCA\|breast	p.R88K (No)	GDSC	JNK-9L	1.0658
SIDM00660	COREAD\|large_intestine	p.T145I (No)	GDSC	JNK-9L	0.1886
SIDM00837	COREAD\|large_intestine	p.K191N (No)	GDSC	JNK-9L	0.4124
SIDM00118	COREAD\|large_intestine	p.D421G (Yes)	GDSC	JNK-9L	1.0193
SIDM00688	DLBC\|B_cell_lymphoma	p.D87H (No)	GDSC	JNK-9L	0.5478
SIDM01031	ESCA\|oesophagus	p.S437F (Yes)	GDSC	JNK-9L	0.6229
SIDM01028	ESCA\|oesophagus	p.S40R (No)	GDSC	JNK-9L	0.6068
SIDM00581	GBM\|glioma	p.T135M (No)	GDSC	JNK-9L	0.2707
SIDM00375	HNSC\|head_and_neck	p.W362S (No)	GDSC	JNK-9L	0.8285
SIDM01237	LIHC\|liver	p.F318Y (No)	GDSC	JNK-9L	0.4007
SIDM01206	NB\|neuroblastoma	p.I124M (No)	GDSC	JNK-9L	0.5419
SIDM01156	SCLC\|lung_small_cell_carcinoma	p.E425* (Yes)	GDSC	JNK-9L	0.2887
SIDM00602	STAD\|stomach	p.A231T (No)	GDSC	JNK-9L	0.2782

Showing 1 to 14 of 14 entries

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All proteins holding degron of PPSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q7L2J0	7SK snRNA methylphosphate capping enzyme	DEG_SPOP_SBC_1	355:359	PPSSS	SPOP	0.9939	More...
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1285:1289	PPSSS	SPOP	0.8542	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	1509:1513	PPSSS	SPOP	0.9954	More...
Q8NC96	Adaptin ear-binding coat-associated protein 1	DEG_SPOP_SBC_1	199:203	PPSSS	SPOP	0.9883	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	444:448	PPSSS	SPOP	0.8502	More...
Q86TB3	Alpha-protein kinase 2	DEG_SPOP_SBC_1	1642:1646	PPSSS	SPOP	0.917	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	82:86	PPSSS	SPOP	0.9981	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	252:256	PPSSS	SPOP	0.9757	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	482:486	PPSSS	SPOP	0.8891	More...
O94983	Calmodulin-binding transcription activator 2	DEG_SPOP_SBC_1	827:831	PPSSS	SPOP	0.9934	More...
Q8IXM2	Chromatin complexes subunit BAP18	DEG_SPOP_SBC_1	117:121	PPSSS	SPOP	0.9693	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	165:169	PPSSS	SPOP	0.8162	More...
Q5T3F8	CSC1-like protein 2	DEG_SPOP_SBC_1	796:800	PPSSS	SPOP	0.9523	More...
O14976	Cyclin-G-associated kinase	DEG_SPOP_SBC_1	781:785	PPSSS	SPOP	0.9989	More...
P51813	Cytoplasmic tyrosine-protein kinase BMX	DEG_SPOP_SBC_1	206:210	PPSSS	SPOP	0.9857	More...
Q92630	Dual specificity tyrosine-phosphorylation-regulated kinase 2	DEG_SPOP_SBC_1	568:572	PPSSS	SPOP	0.987	More...
Q96EV8	Dysbindin	DEG_SPOP_SBC_1	295:299	PPSSS	SPOP	0.9933	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	810:814	PPSSS	SPOP	0.9752	More...
O95714	E3 ubiquitin-protein ligase HERC2	DEG_SPOP_SBC_1	2632:2636	PPSSS	SPOP	0.9299	More...
P50402	Emerin	DEG_SPOP_SBC_1	50:54	PPSSS	SPOP	0.9872	More...
Q9Y2L6	FERM domain-containing protein 4B	DEG_SPOP_SBC_1	799:803	PPSSS	SPOP	0.6205	More...
P04150	Glucocorticoid receptor	DEG_SPOP_SBC_1	405:409	PPSSS	SPOP	0.8508	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	297:301	PPSSS	SPOP	0.9284	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	393:397	PPSSS	SPOP	0.9958	More...
Q8WYB5	Histone acetyltransferase KAT6B	DEG_SPOP_SBC_1	1759:1763	PPSSS	SPOP	0.964	More...

Showing 1 to 25 of 85 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSSS

Degron related mutations and impact score

Drug responses associated with MAPK10 mutations

All proteins holding degron of PPSSS