DegronMD

Uniprot ID: O60885

Source protein: Bromodomain-containing protein 4

Source gene: BRD4

Class: DEG_SPOP_SBC_1

Location: 482:486

E3 ligase: SPOP

DEGRON score: 0.8891

ASA_SCORE: 97.5

COIL: 0.9754

CONS_SCORE: 0.2402

DSS_SCORE: 0.7375

HELIX: 0.0156

FCONS_SCORE: 0.9068

RIG_SCORE: 0.5016

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D491N	TCGA-B5-A11H	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	0.1944
p.D491N	DO42825	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	0.1944
p.P483T	TCGA-DX-A6YT	SARC	TCGA	PPSSS	DEG_SPOP_SBC_1	0.5919
p.P483T	DO220007	SARC	ICGC	PPSSS	DEG_SPOP_SBC_1	0.5919
p.S488G	TCGA-QG-A5Z2	COAD	TCGA	PPSSS	DEG_SPOP_SBC_1	0.7222
p.S488G	DO44096	COAD	ICGC	PPSSS	DEG_SPOP_SBC_1	0.7222
p.S492N	DO227987	COCA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.6111
p.A481D	DO228971	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.3056
p.A481D	DO229015	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.3056
p.S490R	DO229026	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.2222
p.S490R	DO229036	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.2222
p.S485F	DO220900	MELA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.7982
p.V480L	DO229208	THCA	ICGC	PPSSS	DEG_SPOP_SBC_1	0.2778

Drug responses associated with BRD4 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	JQ1	1.4304
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	I-BET-762	16.4678
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	JQ1	8.5878
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	PFI-1	4.3218
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	I-BET-762	1.0934
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	RVX-208	21.139
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	OTX015	0.1709
SIDM00412	UNCLASSIFIED\|lymphoid_neoplasm_other	p.A861V (No)	GDSC	AZD5153	0.0375
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	JQ1	0.8175
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	I-BET-762	27.3861
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	JQ1	7.2794
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	PFI-1	14.8859
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	I-BET-762	5.2898
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	RVX-208	12.449
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	OTX015	0.925
SIDM00951	LAML\|acute_myeloid_leukaemia	p.P723L (No)	GDSC	AZD5153	0.2526
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	JQ1	0.8175
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	I-BET-762	27.3861
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	JQ1	7.2794
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	PFI-1	14.8859
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	I-BET-762	5.2898
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	RVX-208	12.449
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	OTX015	0.925
SIDM00951	LAML\|acute_myeloid_leukaemia	p.W750L (No)	GDSC	AZD5153	0.2526
SIDM00678	BLCA\|bladder	p.R1097H (No)	GDSC	JQ1	4.6801
SIDM00678	BLCA\|bladder	p.R1097H (No)	GDSC	I-BET-762	440.2382
SIDM00678	BLCA\|bladder	p.R1097H (No)	GDSC	JQ1	13.1181
SIDM00678	BLCA\|bladder	p.R1097H (No)	GDSC	PFI-1	27.0273
SIDM00678	BLCA\|bladder	p.R1097H (No)	GDSC	AZD5153	31.728
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	I-BET-762	1.0363
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	JQ1	0.1575
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	PFI-1	1.6233
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	I-BET-762	1.8903
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	RVX-208	24.341
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	OTX015	0.4102
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.R1097H (No)	GDSC	AZD5153	1.2278
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	JQ1	2.3644
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	I-BET-762	15.0909
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	JQ1	0.3551
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	PFI-1	5.7264
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	I-BET-762	14.96
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	RVX-208	135.63
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	OTX015	12.366
SIDM00145	ALL\|lymphoblastic_leukemia	p.P1131A (No)	GDSC	AZD5153	11.404
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	JQ1	2.3644
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	I-BET-762	15.0909
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	JQ1	0.3551
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	PFI-1	5.7264
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	I-BET-762	14.96
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	RVX-208	135.63
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	OTX015	12.366
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1121C (No)	GDSC	AZD5153	11.404
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	JQ1	2.3644
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	I-BET-762	15.0909
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	JQ1	0.3551
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	PFI-1	5.7264
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	I-BET-762	14.96
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	RVX-208	135.63
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	OTX015	12.366
SIDM00145	ALL\|lymphoblastic_leukemia	p.R1097C (No)	GDSC	AZD5153	11.404
SIDM01187	BRCA\|breast	p.T573K (No)	GDSC	JQ1	46.1862
SIDM01187	BRCA\|breast	p.T573K (No)	GDSC	I-BET-762	44.0666
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	JQ1	0.486
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	I-BET-762	3.3856
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	JQ1	12.5115
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	PFI-1	7.7487
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	I-BET-762	2.3254
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	RVX-208	35.167
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	OTX015	0.5221
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	AZD5153	0.1152
SIDM00272	BRCA\|breast	p.H740Y (No)	GDSC	JQ1	0.1636
SIDM00382	GBM\|glioma	p.R1097H (No)	GDSC	JQ1	1.8762
SIDM00382	GBM\|glioma	p.R1097H (No)	GDSC	I-BET-762	72.9243
SIDM00382	GBM\|glioma	p.R1097H (No)	GDSC	JQ1	12.3412
SIDM00382	GBM\|glioma	p.R1097H (No)	GDSC	PFI-1	7.0555
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	JQ1	1.1252
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	I-BET-762	21.0327
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	JQ1	10.556
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	PFI-1	5.674
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	I-BET-762	10.246
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	RVX-208	43.409
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	OTX015	3.6348
SIDM00837	COREAD\|large_intestine	p.S563fs*21 (No)	GDSC	AZD5153	3.4419
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	JQ1	14.9969
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	I-BET-762	24.4638
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	JQ1	11.628
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	PFI-1	16.9266
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	I-BET-762	159.69
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	RVX-208	176.48
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	OTX015	118.89
SIDM00527	COREAD\|large_intestine	p.1363 (No)	GDSC	AZD5153	74.709
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	JQ1	0.2285
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	I-BET-762	0.7772
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	JQ1	8.5734
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	PFI-1	4.8298
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	I-BET-762	1.1894
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	RVX-208	21.578
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	OTX015	0.3864
SIDM01007	ALL\|lymphoblastic_leukemia	p.R1263* (No)	GDSC	AZD5153	0.0865
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	JQ1	2.6614
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	I-BET-762	287.9299
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	JQ1	9.75
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	PFI-1	8.4811
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	I-BET-762	85.054
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	RVX-208	32.519
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	OTX015	116.85
SIDM00082	SKCM\|melanoma	p.E1113delE (No)	GDSC	AZD5153	64.63
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	JQ1	2.835
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	I-BET-762	16.8114
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	JQ1	9.5904
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	PFI-1	11.8791
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	I-BET-762	5.5043
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	RVX-208	89.483
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	OTX015	1.3938
SIDM00856	UNCLASSIFIED\|kidney	p.R1097H (No)	GDSC	AZD5153	0.8312
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	JQ1	1.0699
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	I-BET-762	109.7817
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	JQ1	0.7416
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	PFI-1	6.4733
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	I-BET-762	32.878
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	RVX-208	140.09
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	OTX015	24.927
SIDM01229	NB\|neuroblastoma	p.P1150L (No)	GDSC	AZD5153	16.611
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	JQ1	2.3663
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	I-BET-762	26.2766
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	JQ1	10.9592
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	PFI-1	19.6215
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	I-BET-762	41.267
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	RVX-208	75.332
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	OTX015	9.0252
SIDM00980	STAD\|stomach	p.K535R (No)	GDSC	AZD5153	1.8821
SIDM00235	KIRC\|kidney	p.V1110delV (No)	GDSC	JQ1	0.0517
SIDM00235	KIRC\|kidney	p.V1110delV (No)	GDSC	I-BET-762	518.9565
SIDM00235	KIRC\|kidney	p.V1110delV (No)	GDSC	I-BET-762	193.5
SIDM00235	KIRC\|kidney	p.V1110delV (No)	GDSC	RVX-208	1241.2
SIDM00235	KIRC\|kidney	p.V1110delV (No)	GDSC	OTX015	53.748
SIDM00235	KIRC\|kidney	p.V1110delV (No)	GDSC	AZD5153	34.048
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	JQ1	1.3527
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	I-BET-762	49.241
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	JQ1	4.1244
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	PFI-1	12.8243
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	I-BET-762	18.035
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	RVX-208	129.34
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	OTX015	15.295
SIDM00198	UNCLASSIFIED\|ewings_sarcoma	p.R1097H (No)	GDSC	AZD5153	5.1788
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	JQ1	0.8268
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	I-BET-762	9.1981
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	JQ1	0.7352
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	PFI-1	6.6406
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	I-BET-762	23.931
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	RVX-208	44.067
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	OTX015	16.318
SIDM00844	UNCLASSIFIED\|Burkitt_lymphoma	p.H77Y (No)	GDSC	AZD5153	0.0909
SIDM00938	BRCA\|breast	p.Q36* (No)	GDSC	JQ1	0.8091
SIDM00938	BRCA\|breast	p.Q36* (No)	GDSC	I-BET-762	20.4407
SIDM00938	BRCA\|breast	p.Q36* (No)	GDSC	JQ1	0.314
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	JQ1	0.0493
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	I-BET-762	2.4104
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	JQ1	8.8018
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	PFI-1	2.5282
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	I-BET-762	5.359
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	RVX-208	64.165
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	OTX015	2.1001
SIDM01090	COREAD\|large_intestine	p.E460G (No)	GDSC	AZD5153	1.5437
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	JQ1	0.0493
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	I-BET-762	2.4104
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	JQ1	8.8018
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	PFI-1	2.5282
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	I-BET-762	5.359
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	RVX-208	64.165
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	OTX015	2.1001
SIDM01090	COREAD\|large_intestine	p.T295P (No)	GDSC	AZD5153	1.5437
SIDM00995	UNCLASSIFIED\|skin_other	p.E1113delE (No)	GDSC	JQ1	0.2961
SIDM00995	UNCLASSIFIED\|skin_other	p.E1113delE (No)	GDSC	I-BET-762	161.8689
SIDM00995	UNCLASSIFIED\|skin_other	p.E1113delE (No)	GDSC	JQ1	5.5725
SIDM00995	UNCLASSIFIED\|skin_other	p.E1113delE (No)	GDSC	PFI-1	16.0319
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	JQ1	0.6656
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	I-BET-762	66.2157
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	JQ1	13.2829
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	PFI-1	25.092
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	I-BET-762	55.201
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	RVX-208	440.59
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	OTX015	17.675
SIDM00564	OV\|ovary	p.W81L (No)	GDSC	AZD5153	6.0611
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	JQ1	0.3976
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	I-BET-762	1.2888
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	JQ1	7.6954
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	PFI-1	5.9755
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	I-BET-762	5.6449
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	RVX-208	32.934
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	OTX015	1.3879
SIDM01077	PRAD\|prostate	p.R1097H (No)	GDSC	AZD5153	0.3857
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	JQ1	0.4262
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	I-BET-762	195.2428
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	JQ1	10.3097
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	PFI-1	10.4331
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	I-BET-762	39.801
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	RVX-208	62.179
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	OTX015	22.454
SIDM00333	UCEC\|endometrium	p.C357Y (No)	GDSC	AZD5153	42.735
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	JQ1	0.2974
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	I-BET-762	61.3936
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	JQ1	1.0951
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	PFI-1	10.2788
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	I-BET-762	16.979
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	RVX-208	96.503
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	OTX015	21.915
SIDM00999	BLCA\|bladder	p.R1097H (No)	GDSC	AZD5153	6.4125
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	JQ1	0.2974
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	I-BET-762	61.3936
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	JQ1	1.0951
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	PFI-1	10.2788
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	I-BET-762	16.979
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	RVX-208	96.503
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	OTX015	21.915
SIDM00999	BLCA\|bladder	p.R444C (No)	GDSC	AZD5153	6.4125
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	I-BET-762	20.859
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	JQ1	5.699
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	PFI-1	49.0441
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	I-BET-762	45.177
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	RVX-208	316.56
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	OTX015	13.116
SIDM00217	COREAD\|large_intestine	p.A1268V (No)	GDSC	AZD5153	14.469
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	I-BET-762	20.859
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	JQ1	5.699
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	PFI-1	49.0441
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	I-BET-762	45.177
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	RVX-208	316.56
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	OTX015	13.116
SIDM00217	COREAD\|large_intestine	p.R1256W (No)	GDSC	AZD5153	14.469
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	I-BET-762	20.859
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	JQ1	5.699
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	PFI-1	49.0441
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	I-BET-762	45.177
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	RVX-208	316.56
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	OTX015	13.116
SIDM00217	COREAD\|large_intestine	p.A40T (No)	GDSC	AZD5153	14.469
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	JQ1	51.5138
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	I-BET-762	182.0816
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	JQ1	12.4468
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	PFI-1	28.3601
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	I-BET-762	20.848
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	RVX-208	164.62
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	OTX015	21.788
SIDM01120	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.R1097H (No)	GDSC	AZD5153	12.574
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	JQ1	2.6614
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	I-BET-762	287.9299
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	JQ1	9.75
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	PFI-1	8.4811
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	I-BET-762	85.054
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	RVX-208	32.519
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	OTX015	116.85
SIDM00082	SKCM\|melanoma	p.T73I (No)	GDSC	AZD5153	64.63
SIDM00216	COREAD\|large_intestine	p.A1203T (No)	GDSC	I-BET-762	2.1779
SIDM00216	COREAD\|large_intestine	p.A1203T (No)	GDSC	I-BET-762	6.6864
SIDM00216	COREAD\|large_intestine	p.A1203T (No)	GDSC	RVX-208	34.972
SIDM00216	COREAD\|large_intestine	p.A1203T (No)	GDSC	OTX015	5.0449
SIDM00216	COREAD\|large_intestine	p.A1203T (No)	GDSC	AZD5153	1.5589
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	JQ1	0.6889
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	I-BET-762	22.1191
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	JQ1	14.8593
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	PFI-1	76.6459
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	I-BET-762	6.6596
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	RVX-208	67.087
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	OTX015	4.79
SIDM00150	COREAD\|large_intestine	p.W120* (No)	GDSC	AZD5153	294.27
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	JQ1	0.1746
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	I-BET-762	3.4801
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	JQ1	15.9176
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	PFI-1	9.8795
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	I-BET-762	13.313
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	RVX-208	292.38
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	OTX015	7.248
SIDM00660	COREAD\|large_intestine	p.R1097H (No)	GDSC	AZD5153	0.7983
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	JQ1	0.1746
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	I-BET-762	3.4801
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	JQ1	15.9176
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	PFI-1	9.8795
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	I-BET-762	13.313
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	RVX-208	292.38
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	OTX015	7.248
SIDM00660	COREAD\|large_intestine	p.A292T (No)	GDSC	AZD5153	0.7983
SIDM00660	COREAD\|large_intestine	p.Q235* (No)	GDSC	JQ1	0.1746
SIDM00660	COREAD\|large_intestine	p.Q235* (No)	GDSC	I-BET-762	3.4801
SIDM00660	COREAD\|large_intestine	p.Q235* (No)	GDSC	JQ1	15.9176
SIDM00660	COREAD\|large_intestine	p.Q235* (No)	GDSC	PFI-1	9.8795
SIDM00660	COREAD\|large_intestine	p.Q235* (No)	GDSC	I-BET-762	13.313
SIDM00660	COREAD\|large_intestine	p.Q235* (No)	GDSC	RVX-208	292.38
SIDM00660	COREAD\|large_intestine	p.Q235* (No)	GDSC	OTX015	7.248
SIDM00660	COREAD\|large_intestine	p.Q235* (No)	GDSC	AZD5153	0.7983
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	JQ1	1.8098
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	I-BET-762	502.0155
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	JQ1	7.4455
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	PFI-1	24.1874
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	I-BET-762	29.78
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	RVX-208	240.46
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	OTX015	5.4922
SIDM00359	COREAD\|large_intestine	p.R616W (No)	GDSC	AZD5153	3.427
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	JQ1	0.7048
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	I-BET-762	11.9188
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	JQ1	3.934
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	PFI-1	3.5241
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	I-BET-762	2.8854
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	RVX-208	19.105
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	OTX015	0.7025
SIDM00845	UNCLASSIFIED\|Burkitt_lymphoma	p.A3T (No)	GDSC	AZD5153	0.1013
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	JQ1	2.499
SIDM00739	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	I-BET-762	161.1834
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	JQ1	0.6553
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	I-BET-762	36.6547
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	JQ1	9.5459
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	PFI-1	12.5944
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	I-BET-762	67.938
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	RVX-208	155.56
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	OTX015	21.154
SIDM01095	UNCLASSIFIED\|rhabdomyosarcoma	p.T1212P (No)	GDSC	AZD5153	29.575
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	JQ1	0.3959
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	I-BET-762	26.4252
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	JQ1	9.7441
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	PFI-1	23.2999
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	I-BET-762	278.72
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	RVX-208	332.33
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	OTX015	96.088
SIDM01119	UNCLASSIFIED\|lung_NSCLC_carcinoid	p.A202G (No)	GDSC	AZD5153	26.265
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	JQ1	0.3654
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	I-BET-762	76.3613
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	JQ1	14.2422
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	PFI-1	137.6001
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	I-BET-762	8.0329
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	RVX-208	75.058
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	OTX015	1.163
SIDM00789	COREAD\|large_intestine	p.E1339G (No)	GDSC	AZD5153	0.28
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	JQ1	0.3654
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	I-BET-762	76.3613
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	JQ1	14.2422
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	PFI-1	137.6001
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	I-BET-762	8.0329
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	RVX-208	75.058
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	OTX015	1.163
SIDM00789	COREAD\|large_intestine	p.P750L (No)	GDSC	AZD5153	0.28
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	JQ1	0.3654
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	I-BET-762	76.3613
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	JQ1	14.2422
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	PFI-1	137.6001
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	I-BET-762	8.0329
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	RVX-208	75.058
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	OTX015	1.163
SIDM00789	COREAD\|large_intestine	p.E451G (No)	GDSC	AZD5153	0.28
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.G182delG (No)	GDSC	JQ1	0.9321
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.G182delG (No)	GDSC	I-BET-762	271.4943
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.G182delG (No)	GDSC	JQ1	7.6527
SIDM01218	UNCLASSIFIED\|urogenital_system_other	p.G182delG (No)	GDSC	PFI-1	21.7859
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	JQ1	0.5633
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	I-BET-762	69.2874
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	JQ1	8.5171
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	PFI-1	16.4545
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	I-BET-762	51.757
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	RVX-208	59.165
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	OTX015	9.2643
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	AZD5153	2.7127
SIDM00628	BRCA\|breast	p.R745K (No)	GDSC	JQ1	37.01
SIDM00545	SKCM\|melanoma	p.P784L (No)	GDSC	JQ1	19.0047
SIDM00545	SKCM\|melanoma	p.P784L (No)	GDSC	I-BET-762	237.53
SIDM00545	SKCM\|melanoma	p.P784L (No)	GDSC	JQ1	16.7562
SIDM00545	SKCM\|melanoma	p.P784L (No)	GDSC	PFI-1	12.3569
SIDM00545	SKCM\|melanoma	p.K629* (No)	GDSC	JQ1	19.0047
SIDM00545	SKCM\|melanoma	p.K629* (No)	GDSC	I-BET-762	237.53
SIDM00545	SKCM\|melanoma	p.K629* (No)	GDSC	JQ1	16.7562
SIDM00545	SKCM\|melanoma	p.K629* (No)	GDSC	PFI-1	12.3569
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	JQ1	0.0889
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	I-BET-762	5.2154
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	JQ1	19.3529
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	PFI-1	7.8456
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	I-BET-762	9.5466
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	RVX-208	67.743
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	OTX015	8.3357
SIDM00513	LUAD\|lung_NSCLC_adenocarcinoma	p.R1097H (No)	GDSC	AZD5153	1.3243
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	JQ1	0.2855
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	I-BET-762	1.5369
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	JQ1	8.8691
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	PFI-1	19.8375
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	I-BET-762	7.1915
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	RVX-208	100.95
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	OTX015	2.3039
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.I360V (No)	GDSC	AZD5153	0.6171
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	JQ1	2.9811
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	I-BET-762	125.1316
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	JQ1	16.5418
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	PFI-1	18.1302
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	I-BET-762	343.28
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	RVX-208	1051.7
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	OTX015	57.453
SIDM00218	THCA\|thyroid	p.R1097H (No)	GDSC	AZD5153	40.25
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	JQ1	66.5135
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	I-BET-762	218.0698
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	JQ1	18.3066
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	PFI-1	27.7498
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	I-BET-762	95.138
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	RVX-208	556.97
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	OTX015	55.568
SIDM00890	SKCM\|melanoma	p.R1097H (No)	GDSC	AZD5153	25.766
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	JQ1	1.6868
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	I-BET-762	31.4723
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	JQ1	10.2008
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	PFI-1	52.0761
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	I-BET-762	61.918
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	RVX-208	159.98
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	OTX015	15.271
SIDM01130	LUSC\|lung_NSCLC_squamous_cell_carcinoma	p.M1320V (No)	GDSC	AZD5153	4.8882
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	JQ1	0.1377
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	I-BET-762	0.5177
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	JQ1	6.965
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	PFI-1	4.9932
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	I-BET-762	0.9391
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	RVX-208	12.926
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	OTX015	0.2456
SIDM00457	MM\|myeloma	p.H764Q (No)	GDSC	AZD5153	0.042
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	JQ1	1.1252
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	I-BET-762	21.0327
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	JQ1	10.556
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	PFI-1	5.674
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	I-BET-762	10.246
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	RVX-208	43.409
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	OTX015	3.6348
SIDM00837	COREAD\|large_intestine	p.G742S (No)	GDSC	AZD5153	3.4419
SIDM00281	UNCLASSIFIED\|skin_other	p.S579delS (No)	GDSC	JQ1	1.4281
SIDM00281	UNCLASSIFIED\|skin_other	p.S579delS (No)	GDSC	I-BET-762	212.5266
SIDM00115	HNSC\|head_and_neck	p.D301A (No)	GDSC	JQ1	0.162
SIDM00115	HNSC\|head_and_neck	p.D301A (No)	GDSC	I-BET-762	7.2574
SIDM00115	HNSC\|head_and_neck	p.D301A (No)	GDSC	JQ1	9.8403
SIDM00115	HNSC\|head_and_neck	p.D301A (No)	GDSC	PFI-1	15.2396
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	JQ1	0.9581
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	I-BET-762	95.874
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	JQ1	9.4882
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	PFI-1	6.1114
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	I-BET-762	11.965
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	RVX-208	50.401
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	OTX015	3.7042
SIDM00118	COREAD\|large_intestine	p.S703L (No)	GDSC	AZD5153	0.8672
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	I-BET-762	14.4292
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	JQ1	12.5677
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	PFI-1	7.3447
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	I-BET-762	28.003
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	RVX-208	107.19
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	OTX015	27.715
SIDM00472	OV\|ovary	p.S767C (No)	GDSC	AZD5153	3.7453

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
C9JLW8	Mapk-regulated corepressor-interacting protein 1	DEG_SPOP_SBC_1	22:26	PPSSS	SPOP	0.978	More...
O14497	AT-rich interactive domain-containing protein 1A	DEG_SPOP_SBC_1	252:256	PPSSS	SPOP	0.9757	More...
O14976	Cyclin-G-associated kinase	DEG_SPOP_SBC_1	781:785	PPSSS	SPOP	0.9989	More...
O15534	Period circadian protein homolog 1	DEG_SPOP_SBC_1	100:104	PPSSS	SPOP	0.997	More...
O43516	WAS/WASL-interacting protein family member 1	DEG_SPOP_SBC_1	322:326	PPSSS	SPOP	0.9012	More...
O60885	Bromodomain-containing protein 4	DEG_SPOP_SBC_1	482:486	PPSSS	SPOP	0.8891	More...
O75179	Ankyrin repeat domain-containing protein 17	DEG_SPOP_SBC_1	82:86	PPSSS	SPOP	0.9981	More...
O94851	[F-actin]-monooxygenase MICAL2	DEG_SPOP_SBC_1	1285:1289	PPSSS	SPOP	0.8542	More...
O94979	Protein transport protein Sec31A	DEG_SPOP_SBC_1	961:965	PPSSS	SPOP	0.9968	More...
O94983	Calmodulin-binding transcription activator 2	DEG_SPOP_SBC_1	827:831	PPSSS	SPOP	0.9934	More...
O95243	Methyl-CpG-binding domain protein 4	DEG_SPOP_SBC_1	191:195	PPSSS	SPOP	0.967	More...
O95644	Nuclear factor of activated T-cells, cytoplasmic 1	DEG_SPOP_SBC_1	829:833	PPSSS	SPOP	0.9905	More...
O95714	E3 ubiquitin-protein ligase HERC2	DEG_SPOP_SBC_1	2632:2636	PPSSS	SPOP	0.9299	More...
O95948	One cut domain family member 2	DEG_SPOP_SBC_1	315:319	PPSSS	SPOP	0.9973	More...
P04150	Glucocorticoid receptor	DEG_SPOP_SBC_1	405:409	PPSSS	SPOP	0.8508	More...
P04275	von Willebrand factor	DEG_SPOP_SBC_1	205:209	PPSSS	SPOP	0.9077	More...
P12270	Nucleoprotein TPR	DEG_SPOP_SBC_1	2307:2311	PPSSS	SPOP	0.9266	More...
P49356	Protein farnesyltransferase subunit beta	DEG_SPOP_SBC_1	12:16	PPSSS	SPOP	0.9534	More...
P50402	Emerin	DEG_SPOP_SBC_1	50:54	PPSSS	SPOP	0.9872	More...
P50749	Ras association domain-containing protein 2	DEG_SPOP_SBC_1	80:84	PPSSS	SPOP	0.9712	More...
P51813	Cytoplasmic tyrosine-protein kinase BMX	DEG_SPOP_SBC_1	206:210	PPSSS	SPOP	0.9857	More...
P51825	AF4/FMR2 family member 1	DEG_SPOP_SBC_1	444:448	PPSSS	SPOP	0.8502	More...
P53779	Mitogen-activated protein kinase 10	DEG_SPOP_SBC_1	428:432	PPSSS	SPOP	0.9915	More...
P78426	Homeobox protein Nkx-6.1	DEG_SPOP_SBC_1	47:51	PPSSS	SPOP	0.9986	More...
Q08289	Voltage-dependent L-type calcium channel subunit beta-2	DEG_SPOP_SBC_1	466:470	PPSSS	SPOP	0.9947	More...
Q10587	Thyrotroph embryonic factor	DEG_SPOP_SBC_1	141:145	PPSSS	SPOP	0.9989	More...
Q13950	Runt-related transcription factor 2	DEG_SPOP_SBC_1	29:33	PPSSS	SPOP	0.9835	More...
Q14118	Dystroglycan 1	DEG_SPOP_SBC_1	810:814	PPSSS	SPOP	0.9752	More...
Q14524	Sodium channel protein type 5 subunit alpha	DEG_SPOP_SBC_1	1962:1966	PPSSS	SPOP	0.9554	More...
Q15637	Splicing factor 1	DEG_SPOP_SBC_1	512:516	PPSSS	SPOP	0.8564	More...
Q15911	Zinc finger homeobox protein 3	DEG_SPOP_SBC_1	2774:2778	PPSSS	SPOP	0.9812	More...
Q2M3C7	A-kinase anchor protein SPHKAP	DEG_SPOP_SBC_1	1509:1513	PPSSS	SPOP	0.9954	More...
Q5H9R7	Serine/threonine-protein phosphatase 6 regulatory subunit 3	DEG_SPOP_SBC_1	849:853	PPSSS	SPOP	0.9972	More...
Q5HYW2	NHS-like protein 2	DEG_SPOP_SBC_1	737:741	PPSSS	SPOP	0.9584	More...
Q5JU85	IQ motif and SEC7 domain-containing protein 2	DEG_SPOP_SBC_1	275:279	PPSSS	SPOP	0.9552	More...
Q6VY07	Phosphofurin acidic cluster sorting protein 1	DEG_SPOP_SBC_1	782:786	PPSSS	SPOP	0.998	More...
Q70EL1	Inactive ubiquitin carboxyl-terminal hydrolase 54	DEG_SPOP_SBC_1	1605:1609	PPSSS	SPOP	0.8874	More...
Q7L2J0	7SK snRNA methylphosphate capping enzyme	DEG_SPOP_SBC_1	355:359	PPSSS	SPOP	0.9939	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	297:301	PPSSS	SPOP	0.9284	More...
Q7Z4V5	Hepatoma-derived growth factor-related protein 2	DEG_SPOP_SBC_1	393:397	PPSSS	SPOP	0.9958	More...
Q86TB3	Alpha-protein kinase 2	DEG_SPOP_SBC_1	1642:1646	PPSSS	SPOP	0.917	More...
Q86UD0	Suppressor APC domain-containing protein 2	DEG_SPOP_SBC_1	316:320	PPSSS	SPOP	0.991	More...
Q86UP3	Zinc finger homeobox protein 4	DEG_SPOP_SBC_1	3123:3127	PPSSS	SPOP	0.9592	More...
Q8IXM2	Chromatin complexes subunit BAP18	DEG_SPOP_SBC_1	117:121	PPSSS	SPOP	0.9693	More...
Q8IZD2	Inactive histone-lysine N-methyltransferase 2E	DEG_SPOP_SBC_1	1551:1555	PPSSS	SPOP	0.6018	More...
Q8N3F8	MICAL-like protein 1	DEG_SPOP_SBC_1	387:391	PPSSS	SPOP	0.9626	More...
Q8N5C8	TGF-beta-activated kinase 1 and MAP3K7-binding protein 3	DEG_SPOP_SBC_1	405:409	PPSSS	SPOP	0.9393	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	1931:1935	PPSSS	SPOP	0.8847	More...
Q8TAK6	Oligodendrocyte transcription factor 1	DEG_SPOP_SBC_1	41:45	PPSSS	SPOP	0.9878	More...
Q8TAX7	Mucin-7	DEG_SPOP_SBC_1	179:183	PPSSS	SPOP	0.8542	More...
Q8TAX7	Mucin-7	DEG_SPOP_SBC_1	202:206	PPSSS	SPOP	0.7485	More...
Q8TAX7	Mucin-7	DEG_SPOP_SBC_1	225:229	PPSSS	SPOP	0.9613	More...
Q8WY41	Nanos homolog 1	DEG_SPOP_SBC_1	76:80	PPSSS	SPOP	0.9587	More...
Q8WY91	Peroxynitrite isomerase THAP4	DEG_SPOP_SBC_1	284:288	PPSSS	SPOP	0.9637	More...
Q8WYB5	Histone acetyltransferase KAT6B	DEG_SPOP_SBC_1	1759:1763	PPSSS	SPOP	0.964	More...
Q92630	Dual specificity tyrosine-phosphorylation-regulated kinase 2	DEG_SPOP_SBC_1	568:572	PPSSS	SPOP	0.987	More...
Q92777	Synapsin-2	DEG_SPOP_SBC_1	484:488	PPSSS	SPOP	0.9117	More...
Q96AV8	Transcription factor E2F7	DEG_SPOP_SBC_1	472:476	PPSSS	SPOP	0.9909	More...
Q96EV8	Dysbindin	DEG_SPOP_SBC_1	295:299	PPSSS	SPOP	0.9933	More...
Q96JY6	PDZ and LIM domain protein 2	DEG_SPOP_SBC_1	139:143	PPSSS	SPOP	0.9929	More...
Q96MN9	Zinc finger protein 488	DEG_SPOP_SBC_1	250:254	PPSSS	SPOP	0.8945	More...
Q96SU4	Oxysterol-binding protein-related protein 9	DEG_SPOP_SBC_1	265:269	PPSSS	SPOP	0.9655	More...
Q9BYH1	Seizure 6-like protein	DEG_SPOP_SBC_1	70:74	PPSSS	SPOP	0.9981	More...
Q9BZL6	Serine/threonine-protein kinase D2	DEG_SPOP_SBC_1	234:238	PPSSS	SPOP	0.8427	More...
Q9H3S7	Tyrosine-protein phosphatase non-receptor type 23	DEG_SPOP_SBC_1	1572:1576	PPSSS	SPOP	0.9582	More...
Q9H7S9	Zinc finger protein 703	DEG_SPOP_SBC_1	357:361	PPSSS	SPOP	0.9195	More...
Q9H9P5	Putative E3 ubiquitin-protein ligase UNKL	DEG_SPOP_SBC_1	554:558	PPSSS	SPOP	0.9873	More...
Q9HCK8	Chromodomain-helicase-DNA-binding protein 8	DEG_SPOP_SBC_1	165:169	PPSSS	SPOP	0.8162	More...
Q9NQU5	Serine/threonine-protein kinase PAK 6	DEG_SPOP_SBC_1	273:277	PPSSS	SPOP	0.8149	More...
Q9NR48	Histone-lysine N-methyltransferase ASH1L	DEG_SPOP_SBC_1	1744:1748	PPSSS	SPOP	0.9985	More...
Q9P0X4	Voltage-dependent T-type calcium channel subunit alpha-1I	DEG_SPOP_SBC_1	7:11	PPSSS	SPOP	0.8266	More...
Q9UKI8	Serine/threonine-protein kinase tousled-like 1	DEG_SPOP_SBC_1	758:762	PPSSS	SPOP	0.9913	More...
Q9Y6X0	SET-binding protein	DEG_SPOP_SBC_1	301:305	PPSSS	SPOP	0.9605	More...
Q5T3F8	CSC1-like protein 2	DEG_SPOP_SBC_1	796:800	PPSSS	SPOP	0.9523	More...
Q7RTM1	Proton channel OTOP1	DEG_SPOP_SBC_1	30:34	PPSSS	SPOP	0.9906	More...
Q8NC96	Adaptin ear-binding coat-associated protein 1	DEG_SPOP_SBC_1	199:203	PPSSS	SPOP	0.9883	More...
Q8TBP0	TBC1 domain family member 16	DEG_SPOP_SBC_1	261:265	PPSSS	SPOP	0.6402	More...
Q96PE2	Rho guanine nucleotide exchange factor 17	DEG_SPOP_SBC_1	858:862	PPSSS	SPOP	0.9891	More...
Q96T92	Insulinoma-associated protein 2	DEG_SPOP_SBC_1	332:336	PPSSS	SPOP	0.9181	More...
Q9HAS0	Protein Njmu-R1	DEG_SPOP_SBC_1	32:36	PPSSS	SPOP	0.9877	More...
Q9Y2L6	FERM domain-containing protein 4B	DEG_SPOP_SBC_1	799:803	PPSSS	SPOP	0.6205	More...
Q8IZD0	Sterile alpha motif domain-containing protein 14	DEG_SPOP_SBC_1	284:288	PPSSS	SPOP	0.9891	More...
E7EW31	Proline-rich basic protein 1	DEG_SPOP_SBC_1	998:1002	PPSSS	SPOP	0.9547	More...
Q8N0V1	Putative uncharacterized protein ZNF295-AS1	DEG_SPOP_SBC_1	20:24	PPSSS	SPOP	0.7709	More...
Q96NR7	Putative uncharacterized protein WWC2-AS2	DEG_SPOP_SBC_1	188:192	PPSSS	SPOP	0.9567	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PPSSS

Degron related mutations and impact score

Drug responses associated with BRD4 mutations

All proteins holding degron of PPSSS