DegronMD - Q8WY91(THAP4)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P293L	TCGA-A3-3331	KIRC	TCGA	APPADVTPK	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.0833
p.P293L	TCGA-A3-3331	KIRC	TCGA	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1944
p.P284H	TCGA-AJ-A3BH	UCEC	TCGA	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7694
p.P284H	DO41638	UCEC	ICGC	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7694
p.R481T	TCGA-CN-6994	HNSC	TCGA	RKPMHRE	LIG_APCC_ABBAyCdc20_2	476:482	Mutation altering degron motif	0.6765
p.T308I	TCGA-D3-A8GQ	SKCM	TCGA	APPADVTPK	DEG_SIAH_1	302:310	Mutation altering degron motif	0.5966
p.T308I	DO51246	SKCM	ICGC	APPADVTPK	DEG_SIAH_1	302:310	Mutation altering degron motif	0.5966
p.P490L	TCGA-EE-A29M	SKCM	TCGA	RKPMHRE	LIG_APCC_ABBAyCdc20_2	476:482	Mutation rewiring degron network	0.1111
p.P490L	DO37404	SKCM	ICGC	RKPMHRE	LIG_APCC_ABBAyCdc20_2	476:482	Mutation rewiring degron network	0.1111
p.S288L	TCGA-GN-A268	SKCM	TCGA	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7667
p.S288L	DO37477	SKCM	ICGC	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation altering degron motif	0.7667
p.A305P	TCGA-MN-A4N4	LUAD	TCGA	APPADVTPK	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7503
p.A305P	DO26250	LUAD	ICGC	APPADVTPK	DEG_SIAH_1	302:310	Mutation altering degron motif	0.7503
p.T475M	TCGA-RC-A6M4	LIHC	TCGA	RKPMHRE	LIG_APCC_ABBAyCdc20_2	476:482	Mutation rewiring degron network	0.3056
p.P490T	DO229022	LICA	ICGC	RKPMHRE	LIG_APCC_ABBAyCdc20_2	476:482	Mutation rewiring degron network	0.1111
p.H320Q	DO229036	LICA	ICGC	APPADVTPK	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.0556
p.D277E	DO229037	LICA	ICGC	PPSSS	DEG_SPOP_SBC_1	284:288	Mutation rewiring degron network	0.1389
p.S318R	DO229045	LICA	ICGC	APPADVTPK	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1111
p.V316M	SIDM00214	Colorectal Carcinoma	GDSC	APPADVTPK	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1667
p.V316M	ACH-000955	Colon/Colorectal Cancer	CCLE	APPADVTPK	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1667
p.V316M	SNU-407	large intestine	COSMIC	APPADVTPK	DEG_SIAH_1	302:310	Mutation rewiring degron network	0.1667
p.T475A	GR-ST	haematopoietic and lymphoid tissue	COSMIC	RKPMHRE	LIG_APCC_ABBAyCdc20_2	476:482	Mutation rewiring degron network	0.3056

Kaplan plot for THAP4 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

THAP4

UniProt ID: Q8WY91

Entrez ID: 51078

Protein name: Peroxynitrite isomerase THAP4 (EC 5.99.-.-) (Ferric Homo sapiens nitrobindin) (Hs-Nb(III)) (THAP domain-containing protein 4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for THAP4 in