DegronMD

Uniprot ID: Q8WY91

Source protein: Peroxynitrite isomerase THAP4

Source gene: THAP4

Class: DEG_SIAH_1

Location: 302:310

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9982

ASA_SCORE: 79.8667

COIL: 0.9244

CONS_SCORE: 0.3807

DSS_SCORE: 0.7827

HELIX: 0.0251

FCONS_SCORE: 1.1939

RIG_SCORE: 0.5575

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P293L	TCGA-A3-3331	KIRC	TCGA	APPADVTPK	DEG_SIAH_1	0.0833
p.T308I	TCGA-D3-A8GQ	SKCM	TCGA	APPADVTPK	DEG_SIAH_1	0.5966
p.T308I	DO51246	SKCM	ICGC	APPADVTPK	DEG_SIAH_1	0.5966
p.A305P	TCGA-MN-A4N4	LUAD	TCGA	APPADVTPK	DEG_SIAH_1	0.7503
p.A305P	DO26250	LUAD	ICGC	APPADVTPK	DEG_SIAH_1	0.7503
p.H320Q	DO229036	LICA	ICGC	APPADVTPK	DEG_SIAH_1	0.0556
p.S318R	DO229045	LICA	ICGC	APPADVTPK	DEG_SIAH_1	0.1111
p.V316M	SIDM00214	Colorectal Carcinoma	GDSC	APPADVTPK	DEG_SIAH_1	0.1667
p.V316M	ACH-000955	Colon/Colorectal Cancer	CCLE	APPADVTPK	DEG_SIAH_1	0.1667
p.V316M	SNU-407	large_intestine	COSMIC	APPADVTPK	DEG_SIAH_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8WY91	Peroxynitrite isomerase THAP4	DEG_SIAH_1	302:310	APPADVTPK	SIAH1,SIAH2,SIAH3	0.9982	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons